Power of two: combination of therapeutic approaches involving glucose transporter (GLUT) inhibitors to combat cancer

K Tilekar, N Upadhyay, CV Iancu, V Pokrovsky… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Cancer research of the Warburg effect, a hallmark metabolic alteration in tumors, focused
attention on glucose metabolism whose targeting uncovered several agents with promising …

Universal architecture of bacterial chemoreceptor arrays

…, Z Li, S Chen, A Müller, CV Iancu… - Proceedings of the …, 2009 - National Acad Sciences
Chemoreceptors are key components of the high-performance signal transduction system
that controls bacterial chemotaxis. Chemoreceptors are typically localized in a cluster at the …

Electron cryotomography sample preparation using the Vitrobot

CV Iancu, WF Tivol, JB Schooler, DP Dias… - Nature protocols, 2006 - nature.com
Electron cryotomography is the highest-resolution structural technique currently available that
can be applied to unique objects such as flexible large protein complexes, irregular viruses…

Organization, structure, and assembly of α-carboxysomes determined by electron cryotomography of intact cells

CV Iancu, DM Morris, Z Dou, S Heinhorst… - Journal of molecular …, 2010 - Elsevier
Carboxysomes are polyhedral inclusion bodies that play a key role in autotrophic metabolism
in many bacteria. Using electron cryotomography, we examined carboxysomes in their …

The structure of isolated Synechococcus strain WH8102 carboxysomes as revealed by electron cryotomography

CV Iancu, HJ Ding, DM Morris, DP Dias… - Journal of molecular …, 2007 - Elsevier
Carboxysomes are organelle-like polyhedral bodies found in cyanobacteria and many
chemoautotrophic bacteria that are thought to facilitate carbon fixation. Carboxysomes are …

Crystal structure of a glucose/H+ symporter and its mechanism of action

CV Iancu, J Zamoon, SB Woo… - Proceedings of the …, 2013 - National Acad Sciences
Glucose transporters are required to bring glucose into cells, where it is an essential energy
source and precursor in protein and lipid synthesis. These transporters are involved in …

[HTML][HTML] Differences in salicylic acid glucose conjugations by UGT74F1 and UGT74F2 from Arabidopsis thaliana

AM George Thompson, CV Iancu, KE Neet, JV Dean… - Scientific Reports, 2017 - nature.com
Salicylic acid (SA) is a signaling molecule utilized by plants in response to various stresses.
Through conjugation with small organic molecules such as glucose, an inactive form of SA is …

[HTML][HTML] Transport of anthocyanins and other flavonoids by the Arabidopsis ATP-binding cassette transporter AtABCC2

CE Behrens, KE Smith, CV Iancu, J Choe, JV Dean - Scientific Reports, 2019 - nature.com
Flavonoids have important developmental, physiological, and ecological roles in plants and
are primarily stored in the large central vacuole. Here we show that both an ATP-binding …

Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography

E Lee, BP Fahimian, CV Iancu, C Suloway… - Journal of structural …, 2008 - Elsevier
Electron tomography is currently the highest resolution imaging modality available to study
the 3D structures of pleomorphic macromolecular assemblies, viruses, organelles and cells. …

[HTML][HTML] Inhibition of human GLUT1 and GLUT5 by plant carbohydrate products; insights into transport specificity

AM George Thompson, CV Iancu, TTH Nguyen… - Scientific reports, 2015 - nature.com
Glucose transporters GLUT1 (transports glucose) and GLUT5 (transports fructose), in
addition to their functions in normal metabolism, have been implicated in several diseases …