Molecular profiling of small molecules offers invaluable insights into the function of compounds
and allows for hypothesis generation about small-molecule direct targets and secondary …

Antibiotic persisters are a sub-population of bacteria able to survive in the presence of
bactericidal antibiotic despite the lack of heritable drug resistance mechanisms. This …

Mycobacterium tuberculosis (Mtb) is a globally distributed bacterial pathogen whose population
structure has largely been shaped by the activities of its obligate human host. Oceania …

Genome sequencing and assembly of viral genomes within the Herpesviridae family,
particularly herpes simplex virus (HSV), have been challenging due to the large size (~154 Kb), …

The electroencephalogram (EEG) records the electrical activity of the brain and enables
effects of anaesthetic drugs on brain functioning to be monitored. Identification of genes …

Phenotypic testing for drug susceptibility of Mycobacterium tuberculosis is critical to basic
research and managing the evolving problem of antimicrobial resistance in tuberculosis …

Despite New Zealand being a low-tuberculosis (TB) burden country, there are disproportionately
high rates of TB in particular populations. Here, we report a rapid molecular diagnosis …

Māori, the Indigenous people of New Zealand, have higher notification rates of tuberculosis
compared with New Zealand Europeans. 2 In addition, a New Zealand unique strain known …

Phthiocerol dimycocerosate (PDIM) is an essential virulence lipid of Mycobacterium
tuberculosis. In vitro culturing rapidly selects for spontaneous mutations that cause PDIM loss …

In 2020 the WHO reported an estimated 10 million people contracted tuberculosis and 1.5
million died from the disease, making it the second most deadly infectious disease behind …