This review presents our current understanding of the pathophysiology and potential treatment
strategies with respect to mitochondrial disease in children. We focus on pathologies due …

Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA
damage and the maintenance of genomic diversity and stability. The active form of this DNA-…

Background. There is a recent trend of a worldwide increase in the incidence of autistic spectrum
disorder. Early identification and intervention have proved to be beneficial. The original …

Various types of single-cell analyses are now extensively used to answer many biological
questions, and with this growth in popularity, potential drawbacks to these methods are also …

Real-time nucleic acid amplification methods can be extremely useful for the identification
and quantitation of nucleic acid analytes, but are more difficult to adapt to protein or other …

When oligonucleotide probes are microinjected into cells to image the distribution of RNAs,
they are rapidly sequestered into the nucleus. As a result, it is difficult to detect mRNAs in the …

Coenzyme Q 10 (CoQ 10 ) is an endogenously synthesized lipid molecule. It is best known
for its role as a cofactor within the mitochondrial respiratory chain where it functions in …

OBJECTIVE. The need for radiologic surveillance of spinal tumors in children with
neurofibromatosis 1 is controversial and unresolved. We aimed to determine the incidence of spinal …

Background Rapid whole-exome sequencing (rWES) offers the potential for early diagnosis-predicated
precision medicine. Previous evidence focused predominantly on infants from …

Exogenous metabolites from microbial and dietary origins have profound effects on host
metabolism. Here, we report that a sub-population of lipid droplets (LDs), which are conserved …