User profiles for C. W. Tschumi

Christopher Tschumi

University of Texas at El Paso
Verified email at utep.edu
Cited by 247

Diverse actions of the modulatory peptide neurotensin on central synaptic transmission

CW Tschumi, MJ Beckstead - European Journal of …, 2019 - Wiley Online Library
… transmission - Tschumi - 2019 - European Journal of Neuroscience - Wiley Online Library
… B receptor-mediated IPSCs in these neurons (Tschumi & Beckstead, 2018), suggesting that …

[HTML][HTML] Ventral tegmental area astrocytes orchestrate avoidance and approach behavior

…, EA Szoeke, K Thangamani, CW Tschumi… - Nature …, 2019 - nature.com
The ventral tegmental area (VTA) is a heterogeneous midbrain structure, containing neurons
and astrocytes, that coordinates behaviors by integrating activity from numerous afferents. …

Translating the atypical dopamine uptake inhibitor hypothesis toward therapeutics for treatment of psychostimulant use disorders

…, AM Abramyan, AJ Avelar, CW Tschumi… - …, 2019 - nature.com
Medication-assisted treatments are unavailable to patients with cocaine use disorders. Efforts
to develop potential pharmacotherapies have led to the identification of a promising lead …

Neurotensin release from dopamine neurons drives long-term depression of substantia nigra dopamine signaling

CW Tschumi, HE Blankenship, R Sharma… - Journal of …, 2022 - Soc Neuroscience
Midbrain dopamine neurons play central physiological roles in voluntary movement, reward
learning, and motivated behavior. Inhibitory signaling at somatodendritic dopamine D2 …

Autism-associated mutations in KV7 channels induce gating pore current

…, T Lantin, CW Tschumi… - Proceedings of the …, 2021 - National Acad Sciences
Autism spectrum disorder (ASD) adversely impacts >1% of children in the United States,
causing social interaction deficits, repetitive behaviors, and communication disorders. Genetic …

Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson's model

WB Lynch, CW Tschumi, AL Sharpe… - Movement …, 2018 - Wiley Online Library
Background Parkinson's disease is characterized by the progressive loss of dopamine
neurons in the substantia nigra, leading to severe motor deficits. Although the disease likely …

Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABAA and GABAB receptor-mediated synaptic input

CW Tschumi, MJ Beckstead - Neuropharmacology, 2018 - Elsevier
Midbrain dopamine neurons play physiological roles in many processes including reward
learning and motivated behavior, and are tonically inhibited by γ-aminobutyric acid (GABA)…

Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons

E Piccart, CW Tschumi, MJ Beckstead - European …, 2019 - Elsevier
Phencyclidine (PCP) administration is commonly used to model schizophrenia in laboratory
animals. While PCP is well-characterized as an antagonist of glutamate-sensitive N-methyl-…

A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine

CW Tschumi, AW Daszkowski, AL Sharpe… - Addiction …, 2020 - Wiley Online Library
A history of ethanol drinking increases locomotor stimulation and blunts enhancement of
dendritic dopamine transmission by methamphetamine - Tschumi - 2020 - Addiction Biology - …

Depression of substantia nigra dopamine transmission is driven by retrograde neurotensin release and is enhanced by methamphetamine self-administration

CW Tschumi, R Sharma, WB Lynch, AL Sharpe… - bioRxiv, 2019 - biorxiv.org
Midbrain dopamine neurons play central roles in reward learning and motivated behavior,
and inhibition at somatodendritic dopamine D2 receptor (D2R) synapses blunts …