User profiles for C. Alloza
Clara Alloza, PhDAssociate Director in Healthcare Analytics and AI, AstraZeneca Verified email at astrazeneca.com Cited by 4728 |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
[HTML][HTML] Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …
understood, and reported disease effects on the brain vary widely between studies. In an …
Sex differences in the adult human brain: evidence from 5216 UK biobank participants
Sex differences in the human brain are of interest for many reasons: for example, there are
sex differences in the observed prevalence of psychiatric disorders and in some …
sex differences in the observed prevalence of psychiatric disorders and in some …
[HTML][HTML] Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …
studies have identified common risk variants which have progressively increased in number …
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …
[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium …
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium …
Associations between vascular risk factors and brain MRI indices in UK Biobank
Aims Several factors are known to increase risk for cerebrovascular disease and dementia,
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …
Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders
…, C Abé, A Anticevic, M Alda, A Aleman, C Alloza… - JAMA …, 2021 - jamanetwork.com
Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …
thickness across many psychiatric disorders. The underlying neurobiology behind these …
[HTML][HTML] Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega-and meta-analyses across 3033 individuals
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the
pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have …
pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have …
[HTML][HTML] Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments,
age-related chronic disease, and premature mortality. We investigated evidence for advanced …
age-related chronic disease, and premature mortality. We investigated evidence for advanced …