User profiles for C. Alloza

Clara Alloza, PhD

Associate Director in Healthcare Analytics and AI, AstraZeneca
Verified email at astrazeneca.com
Cited by 4728

Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

…, SP Hagenaars, J Ward, EM Wigmore, C Alloza… - Nature …, 2019 - nature.com
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

[HTML][HTML] Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

…, I Agartz, C Alloza, OA Andreassen, C Arango… - Molecular …, 2018 - nature.com
The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …

Sex differences in the adult human brain: evidence from 5216 UK biobank participants

…, X Shen, MV Lombardo, LM Reus, C Alloza… - Cerebral …, 2018 - academic.oup.com
Sex differences in the human brain are of interest for many reasons: for example, there are
sex differences in the observed prevalence of psychiatric disorders and in some …

[HTML][HTML] Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

…, RE Marioni, G Davies, JRI Coleman, C Alloza… - Nature …, 2018 - nature.com
Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …

Genetic variants associated with longitudinal changes in brain structure across the lifespan

…, CD Whelan, M Aghajani, C Alloza… - Nature …, 2022 - nature.com
Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

[HTML][HTML] Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA

…, C Alloza, C Arango, J Janssen, C Díaz-Caneja… - Neuroimage, 2020 - Elsevier
A common limitation of neuroimaging studies is their small sample sizes. To overcome this
hurdle, the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium …

Associations between vascular risk factors and brain MRI indices in UK Biobank

…, MC Barbu, L De Nooij, LM Reus, C Alloza… - European heart …, 2019 - academic.oup.com
Aims Several factors are known to increase risk for cerebrovascular disease and dementia,
but there is limited evidence on associations between multiple vascular risk factors (VRFs) …

Virtual histology of cortical thickness and shared neurobiology in 6 psychiatric disorders

…, C Abé, A Anticevic, M Alda, A Aleman, C Alloza… - JAMA …, 2021 - jamanetwork.com
Importance Large-scale neuroimaging studies have revealed group differences in cortical
thickness across many psychiatric disorders. The underlying neurobiology behind these …

[HTML][HTML] Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega-and meta-analyses across 3033 individuals

…, F Hozer, S Sarrazin, C Abé, M Alda, C Alloza… - …, 2019 - nature.com
Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the
pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have …

[HTML][HTML] Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium

C Constantinides, LKM Han, C Alloza… - Molecular …, 2023 - nature.com
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments,
age-related chronic disease, and premature mortality. We investigated evidence for advanced …