The transcription factor HIF1A is a key mediator of the cellular response to hypoxia. Despite
the importance of HIF1A in homeostasis and various pathologies, little is known about how it …

Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis,
followed by pyruvate oxidation in the mitochondria. These processes are linked by the …

… Western blot analysis of livers from mice at 30 C and 4 C showed increases in Cpt1b and
Octn2. In contrast, there were no detectable changes in gene expression of Cpt1b, Octn2, CrAT…

Compared to their differentiated progeny, stem cells are often characterized by distinct
metabolic landscapes that emphasize anaerobic glycolysis and a lower fraction of mitochondrial …

Although metabolic adaptations have been demonstrated to be essential for tumor cell
proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that …

… of 250C. The gas chromatograph had an initial temperature of 67C for one minute followed
by a 50C/min ramp to 197C, a second ramp of 10C/minute up to 325C began immediately …

… < 0.05) in BAT at 4C versus room temperature (N = 5). (c) Heat map of relative normalized
changes in BAT (c) and serum (e) metabolites at 30C, 23C, and 4C. Dendograms illustrate …

… held at 250C. A 10:… C for one minute followed by a 40C/minute ramp to 110C and a hold
time of 2 minutes. This was followed by a second 5C/minute ramp to 250C, a third ramp to 350C, …

… (C) Flow cytometry analysis of BrdU incorporation following 5 d of ΔNp63α knockdown. (D)
Heat map and Venn diagrams of microarray results following 48 h of ΔNp63α knockdown or …

The transcription factor Oct1/Pou2f1 promotes poised gene expression states, mitotic stability,
glycolytic metabolism and other characteristics of stem cell potency. To determine the …