User profiles for C. Blach

Charles Black

Brookhaven National Laboratory
Verified email at bnl.gov
Cited by 17939

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—an emerging role for gut microbiome

…, LSJ Williams, JD Tenenbaum, C Blach… - Alzheimer's & …, 2019 - Elsevier
… Data management and medication term mapping were carried out by Tenenbaum and
Blach. Concept and design of the article were performed by Kaddurah-Daouk lead concept and …

Metabolic network failures in Alzheimer's disease: A biochemical road map

…, JR Jack, A Motsinger-Reif, SL Risacher, C Blach… - Alzheimer's & …, 2017 - Elsevier
… as a mean [ 11 C]PiB PET … C]PiB and [ 18 F]Florbetapir PET images using the same pipeline
and adjusting the locally derived cutoffs to best match either the previously reported [ 11 C]…

Scleroderma (systemic sclerosis): classification, subsets and pathogenesis

EC LeRoy, CM Black, R Fleischmajer… - J …, 1988 - api.taylorfrancis.com
A subclassification of SSc patients is proposed by a group of experienced investigators. The
subsets are defined by skin involvement with limited cutaneous SSc (lcSSc) patients having …

Ultrahigh-density nanowire arrays grown in self-assembled diblock copolymer templates

…, T Shibauchi, L Krusin-Elbaum, K Guarini, CT Black… - Science, 2000 - science.org
… Annealing the diblock copolymer film for 14 hours at 165C, above the glass transition
temperature of both components (105C for PS and 115C for PMMA) under an applied electric field (…

[HTML][HTML] Bosentan therapy for pulmonary arterial hypertension

…, RJ Barst, N Galie, CM Black… - … England Journal of …, 2002 - Mass Medical Soc
Background Endothelin-1 is a potent vasoconstrictor and smooth-muscle mitogen. In a
preliminary study, the orally administered dual endothelin-receptor antagonist bosentan improved …

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: relationship to neuroimaging and CSF biomarkers

…, M Arnold, SL Risacher, G Louie, C Blach… - Alzheimer's & …, 2019 - Elsevier
… Author links open overlay panel Kwangsik Nho a 1 , Alexandra Kueider-Paisley b 1 , Siamak
MahmoudianDehkordi b 1 , Matthias Arnold b c , Shannon L. Risacher a , Gregory Louie b , …

[PDF][PDF] Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer's disease

…, R Kaddurah-Daouk, PM Doraiswamy, C Blach… - Cell Reports …, 2020 - cell.com
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …

Association of altered liver enzymes with Alzheimer disease diagnosis, cognition, neuroimaging measures, and cerebrospinal fluid biomarkers

…, M Arnold, SL Risacher, G Louie, C Blach… - JAMA network …, 2019 - jamanetwork.com
C, Increased AST to ALT ratio values were significantly associated with increased amyloid-β
deposition in the bilateral parietal lobes and the right temporal lobe. D, Increased AST to …

[HTML][HTML] Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome

…, LS John-Williams, JD Tenenbaum, C Blach… - Nature …, 2020 - nature.com
Late-onset Alzheimer’s disease (AD) can, in part, be considered a metabolic disease. Besides
age, female sex and APOE ε4 genotype represent strong risk factors for AD that also give …

The biology of cancer metastasis and implications for therapy

IJ Fidler, CM Blach - Current problems in surgery, 1987 - Elsevier
To produce a clinically relevant metastasis, malignant tumor cells must complete a
sequence of potentially lethal interactions with host homeostatic mechanisms, which include …