PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple biological
processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN is a …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphatidylinositol 3-kinase
(PI3K)/AKT constitute an important pathway regulating the signaling of multiple …

Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

INTRODUCTION The ectopic expression of transcription factors OCT4, SOX2, KLF4, and
cMYC (OSKM) enables reprogramming of adult differentiated cells into pluripotent cells, known …

The brain microenvironment imposes a particularly intense selective pressure on metastasis-initiating
cells, but successful metastases bypass this control through mechanisms that are …

… by phosphorylating Cdc25-A and Cdc25-C phosphatases and the kinase c-Tak1.94-96 …
Carmen Blanco-Aparicio is head of the Section of Biology at Experimental Therapeutic program …

… Author links open overlay panel Carmen Blanco-Aparicio a , Amancio Carnero b c …
Later, studies addressing the predisposition of Pim1 transgenic mice through c-myc and N-myc …

With the idea to discover novel genes involved in proliferation, we have performed a genome-wide
loss-of-function genetic screen to identify additional putative tumor suppressor genes. …

… Samples were incubated in blocking solution (IPBS 3% BSA), followed by incubation at 37C
… C. Blanco-Aparicio and J. Torres were supported by fellowships from Bancaja and Instituto …

PIM serine/threonine kinases are overexpressed, translocated, or amplified in multiple B-cell
lymphoma types. We have explored the frequency and relevance of PIM expression in …