Mechanisms of disease: pathway-selective insulin resistance and microvascular complications of diabetes

PH Groop, C Forsblom, MC Thomas - Nature clinical practice …, 2005 - nature.com
Resistance to the actions of insulin is strongly associated with the microvascular complications
of diabetes. To the extent that insulin resistance leads to hyperglycemia, dyslipidemia …

Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies.

…, B Snickars, K Lahti, C Forsblom, C Saloranta… - Diabetes, 1999 - Am Diabetes Assoc
The aim of the study was 1) to establish the prevalence of GAD antibodies (GADab) in a
population-based study of type 2 diabetes in western Finland, 2) to genetically and …

The presence and severity of chronic kidney disease predicts all-cause mortality in type 1 diabetes

…, M Saraheimo, K Hietala, O Heikkilä, C Forsblom - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVES This study aimed to identify clinical features associated with premature mortality
in a large contemporary cohort of adults with type 1 diabetes. RESEARCH DESIGN AND …

Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease

…, MT Lindenmeyer, C Forsblom… - Journal of the …, 2013 - journals.lww.com
… We performed immunostaining with an antibody for cytochrome C oxidase (complex IV)
on … There was a reduction of mitochondrial cytochrome C oxidase in the diabetic kidneys …

Metabolic syndrome in type 1 diabetes: association with diabetic nephropathy and glycemic control (the FinnDiane study)

LM Thorn, C Forsblom, J Fagerudd, MC Thomas… - Diabetes …, 2005 - Am Diabetes Assoc
OBJECTIVE—The aim of this study was to estimate the prevalence of the metabolic syndrome
in Finnish type 1 diabetic patients and to assess whether it is associated with diabetic …

Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects

L Groop, C Forsblom, M Lehtovirta, T Tuomi… - Diabetes, 1996 - Am Diabetes Assoc
Although a strong genetic susceptibility has been established for NIDDM and a maternal
transmission of the disease predominates in some populations, a relationship between parental …

[HTML][HTML] Diabetic nephropathy is associated with low-grade inflammation in type 1 diabetic patients

M Saraheimo, AM Teppo, C Forsblom, J Fagerudd… - Diabetologia, 2003 - Springer
Aims/hypothesis Increased concentrations of C-reactive protein and interleukin-6, a finding
suggestive of the presence of inflammation, have been observed in Type 2 diabetes. In such …

The association between dietary sodium intake, ESRD, and all-cause mortality in patients with type 1 diabetes

MC Thomas, J Moran, C Forsblom, V Harjutsalo… - Diabetes …, 2011 - Am Diabetes Assoc
OBJECTIVE Many guidelines recommend reduced consumption of salt in patients with type
1 diabetes, but it is unclear whether dietary sodium intake is associated with mortality and …

Bacterial endotoxin activity in human serum is associated with dyslipidemia, insulin resistance, obesity, and chronic inflammation

…, PJ Pussinen, J Syrjänen, C Forsblom… - Diabetes …, 2011 - Am Diabetes Assoc
OBJECTIVE To investigate whether bacterial lipopolysaccharide (LPS) activity in human
serum is associated with the components of the metabolic syndrome (MetS) in type 1 diabetic …

[HTML][HTML] Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes—indication of an increased environmental pressure?

…, AP Laine, HK Åkerblom, PH Groop, C Forsblom… - Diabetologia, 2003 - Springer
Aims/hypothesis The incidence of Type 1 diabetes has increased 2.5 times during the time
period from 1966 to 2000 in Finland—a general trend seen in almost all developed countries …