Objectives: To undertake a systematic review of the effectiveness and costs of different
guideline development, dissemination and implementation strategies. To estimate the resource …

… Cynthia Fraser developed all search strategies. Ruth Thomas conducted the search and
screened all references identified by the search strategy for potentially relevant studies. Two …

… The studies were relatively small; studies that allocated to study arms by cluster (C-RCTs,
C-CCTs, CBAs) had a median number of 7 units per arm (interquartile range 1 to 24). The …

The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease,
contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular …

A novel influenza A (H1N1) virus has spread rapidly across the globe. Judging its pandemic
potential is difficult with limited data, but nevertheless essential to inform appropriate health …

An approach for genome analysis based on sequencing and assembly of unselected pieces
of DNA from the whole chromosome has been applied to obtain the complete nucleotide …

The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium
genome, the smallest known genome of any free-living organism, has been determined by whole…

To the Editor: We recently reported (April 18 issue) 1 the sustained correction of X-linked
severe combined immunodeficiency disease by ex vivo, retrovirally mediated transfer of the γc …

The parasite Plasmodium falciparum is responsible for hundreds of millions of cases of malaria,
and kills more than one million African children annually. Here we report an analysis of …

Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590
predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed …