The TNF-related apoptosis-inducing ligand, TRAIL, has been shown to selectively kill tumour
cells. This property has made TRAIL and agonistic antibodies against its death inducing …

Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however, …

… Christoph Emmerich and Philip Cohen designed, and Christoph Emmerich performed
the experiments. Philip Cohen and Christoph Emmerich wrote the paper. …

Members of the tumour necrosis factor (TNF) receptor superfamily have important functions
in immunity and inflammation. Recently linear ubiquitin chains assembled by a complex …

TNF is a key inflammatory cytokine. Using a modified tandem affinity purification approach,
we identified HOIL-1 and HOIP as functional components of the native TNF-R1 signaling …

Polyubiquitin (pUb) chains formed between the C terminus of ubiquitin and lysine 63 (K63)
or methionine 1 (M1) of another ubiquitin have been implicated in the activation of the …

… Christoph Emmerich developed the Halo-NEMO method for capturing and identifying K63-pUb
and linear-pUb chains, the assay of the endogenous LUBAC and contributed ideas. Sam …

Dimethyl fumarate (DMF) possesses anti-inflammatory properties and is approved for the
treatment of psoriasis and multiple sclerosis. While clinically effective, its molecular target has …

It is widely accepted that the essential role of TRAF6 in vivo is to generate the Lys63-linked
ubiquitin (K63-Ub) chains needed to activate the “master” protein kinase TAK1. Here, we …

We have reported previously that activation of the MyD88-signaling network rapidly induces
the formation of hybrid ubiquitin chains containing both Lys63-linked and Met1-linked …