Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." …

… It has also been shown that oligomeric Aβ can interfere indirectly with LTP through an
inhibition of a ubiquitin C-terminal hydrolase (UCH). This enzyme enhances recycling of ubiquitin, …

… Signaling downstream from these receptors regulates APPsα and Aβ secretion by
engaging intermediates including protein kinase C, protein kinase A, phosphatidylinositol-3-kinase, …

… One explanation for our results is that small amounts of Af8-containing C-terminal fragments
of 8-APP (and perhaps even full-length (8-APP) are slowly released during normal cellular …

… Additional artificial mutations can also be examined in vitro to define the amino-acid
specificities of the proteases that cleave at the N and C termini of A3. Analysis of the Swedish …

… during recovery (Figure 1C; Figures S1A–S1C and Table S1). Apoe was reciprocally
upregulated (Figure 1C), which we validated by quantitative real-time PCR (qPCR) in two other …

Expansion of a GGGGCC hexanucleotide repeat upstream of the C9orf72 coding region is the
most common cause of familial frontotemporal lobar degeneration and amyotrophic lateral …

… 7 C), supporting our conclusion that we can stimulate Aβ … in methanol for 4 min at –20C.
Fixed cells were incubated for 1 … at 10C, briefly washed, and further incubated for 45 min at 10C …

… CD measurements were carried out on a Jasco J720 spectropolarimeter at 4C. The path
length of the quartz cell was 0.1 mm. The measurements were performed at a peptide …

We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …