User profiles for C. Kaczorowski
Catherine KaczorowskiElinor Levine Professor, The University of Michigan Verified email at med.umich.edu Cited by 2303 |
[HTML][HTML] Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease
Diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) arise from
complex interactions of genetic and environmental factors, with genetic variants regulating …
complex interactions of genetic and environmental factors, with genetic variants regulating …
[HTML][HTML] Translational approaches to understanding resilience to Alzheimer's disease
Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-associated
pathology are said to be ‘resilient' to AD. Identifying mechanisms underlying …
pathology are said to be ‘resilient' to AD. Identifying mechanisms underlying …
[HTML][HTML] Cognitive reserve in model systems for mechanistic discovery: The importance of longitudinal studies
…, G Kempermann, PR Rapp, CC Kaczorowski… - Frontiers in aging …, 2021 - frontiersin.org
The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …
models, directed at understanding and modifying the relationship between cognition and …
[PDF][PDF] Meta-analysis of the Alzheimer's disease human brain transcriptome and functional dissection in mouse models
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …
Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus
…, S Guyot, C Bjørbaek, C Kaczorowski… - Journal of …, 2014 - Soc Neuroscience
The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food intake
and a primary area for the action of leptin in the CNS. In lean mice, the adipokine leptin …
and a primary area for the action of leptin in the CNS. In lean mice, the adipokine leptin …
Merged magnetic resonance and light sheet microscopy of the whole mouse brain
…, A Hall, K Hornburg, CC Kaczorowski… - Proceedings of the …, 2023 - National Acad Sciences
We have developed workflows to align 3D magnetic resonance histology (MRH) of the mouse
brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We …
brain with light sheet microscopy (LSM) and 3D delineations of the same specimen. We …
[PDF][PDF] Harnessing genetic complexity to enhance translatability of Alzheimer's disease mouse models: a path toward precision medicine
An individual's genetic makeup plays a large role in determining susceptibility to Alzheimer's
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …
disease (AD) but has largely been ignored in preclinical studies. To test the hypothesis that …
Genetic variants and functional pathways associated with resilience to Alzheimer's disease
Approximately 30% of older adults exhibit the neuropathological features of Alzheimer’s
disease without signs of cognitive impairment. Yet, little is known about the genetic factors that …
disease without signs of cognitive impairment. Yet, little is known about the genetic factors that …
Memory deficits are associated with impaired ability to modulate neuronal excitability in middle-aged mice
CC Kaczorowski, JF Disterhoft - Learning & memory, 2009 - learnmem.cshlp.org
Normal aging disrupts hippocampal neuroplasticity and learning and memory. Aging deficits
were exposed in a subset (30%) of middle-aged mice that performed below criterion on a …
were exposed in a subset (30%) of middle-aged mice that performed below criterion on a …
Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease
Accumulations of β-amyloid (Aβ) contribute to neurological deficits associated with Alzheimer's
disease (AD). The effects of Aβ on basal neuronal excitability and learning-related AHP …
disease (AD). The effects of Aβ on basal neuronal excitability and learning-related AHP …