The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to
identify somatic variants across thousands of tumours. Here we present data and analytical …

Background The genetic alterations responsible for an adverse outcome in most patients
with acute myeloid leukemia (AML) are unknown. Methods Using massively parallel DNA …

Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive
breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, …

Most mutations in cancer genomes are thought to be acquired after the initiating event,
which may cause genomic instability and drive clonal evolution. However, for acute myeloid …

Recent genomic analyses of pathologically defined tumor types identify "within-a-tissue"
disease subtypes. However, the extent to which genomic signatures are shared across tissues …

The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

To correlate the variable clinical features of oestrogen-receptor-positive breast cancer with
somatic alterations, we studied pretreatment tumour biopsies accrued from patients in two …

Comprehensive multiplatform analysis of 80 uveal melanomas (UM) identifies four molecularly
distinct, clinically relevant subtypes: two associated with poor-prognosis monosomy 3 (M3…

We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone
receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 …