A SARS-CoV-2 variant carrying the Spike protein amino acid change D614G has become
the most prevalent form in the global pandemic. Dynamic tracking of variant frequencies …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein acquired
a D614G mutation early in the pandemic that confers greater infectivity and is now the …

INTRODUCTION A major goal of HIV-1 vaccine development is to identify immunogens capable
of inducing protective titers of broadly neutralizing antibodies (bNAbs) against circulating…

We have developed an analysis pipeline to facilitate real-time mutation tracking in SARS-CoV-2,
focusing initially on the Spike (S) protein because it mediates infection of human cells …

T follicular helper (Tfh) cells are required to develop germinal center (GC) responses and
drive immunoglobulin class switch, affinity maturation, and long-term B cell memory. In this …

Background. A recombinant canarypox vector expressing human immunodeficiency virus
type 1 (HIV-1) Gag, Pro, and membrane-linked gp120 (vCP1521), combined with a bivalent …

The envelope glycoprotein trimer mediates HIV-1 entry into cells. The trimer is flexible, fluctuating
between closed and more open conformations and sometimes sampling the fully open, …

… C (including subtype CRF07, which is almost entirely a C clade virus in the Env region) we
used 74 sera and 75 isolates. The non-B/non-C data … included various fragments of B and C. …

The development of stabilized recombinant HIV envelope trimers that mimic the virion surface
molecule has increased enthusiasm for a neutralizing antibody (nAb)-based HIV vaccine. …

We recently derived a CD4-independent virus from HIV-1/IIIB, termed IIIBx, which interacts
directly with the chemokine receptor CXCR4 to infect cells. To address the underlying …