User profiles for C. Lambing
Christophe LambingGroup Leader, Rothamsted Research Verified email at rothamsted.ac.uk Cited by 2095 |
Understanding and manipulating meiotic recombination in plants
… For example, a change in temperature from 22C to 30C caused a reduction in chiasmata
and seed set in barley. However, the distribution of COs was altered, and there were …
and seed set in barley. However, the distribution of COs was altered, and there were …
Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data
DW Dempster, CL Lambing, PJ Kostenuik, A Grauer - Clinical therapeutics, 2012 - Elsevier
… Transition to denosumab also produced significantly greater reductions in bone turnover
markers compared with continued alendronate (serum C-telopeptide and intact NTX, specific …
markers compared with continued alendronate (serum C-telopeptide and intact NTX, specific …
The genetic and epigenetic landscape of the Arabidopsis centromeres
…, A Schmücker, T Mandáková, B Jamge, C Lambing… - Science, 2021 - science.org
INTRODUCTION The centromeres of eukaryotic chromosomes assemble the multiprotein
kinetochore complex and thereby position attachment to the spindle microtubules, allowing …
kinetochore complex and thereby position attachment to the spindle microtubules, allowing …
[HTML][HTML] Rewiring meiosis for crop improvement
… (B,C) Non-reductional meiotic divisions resulting in unreduced (2n) meiotic products. First
division restitution (FDR; B) and second division restitution (SDR; C) lead to different levels of …
division restitution (FDR; B) and second division restitution (SDR; C) lead to different levels of …
Nucleosomes and DNA methylation shape meiotic DSB frequency in Arabidopsis thaliana transposons and gene regulatory regions
… We generated a 6×Myc translational fusion at the C terminus of A. thaliana SPO11-1, driven
by the endogenous promoter, which fully complements spo11-1 infertility and crossover …
by the endogenous promoter, which fully complements spo11-1 infertility and crossover …
[HTML][HTML] Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3
M Ferdous, JD Higgins, K Osman, C Lambing… - PLoS …, 2012 - journals.plos.org
In this study we have analysed AtASY3, a coiled-coil domain protein that is required for
normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein …
normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein …
Natural variation and dosage of the HEI10 meiotic E3 ligase control Arabidopsis crossover recombination
… Therefore, we postulate that the HEI10 C-terminal R264 variant may alter substrate
recognition efficiency and SUMO/ubiquitin transfer during regulation of meiotic recombination. …
recognition efficiency and SUMO/ubiquitin transfer during regulation of meiotic recombination. …
Epigenetic activation of meiotic recombination near Arabidopsis thaliana centromeres via loss of H3K9me2 and non-CG DNA methylation
… (C) Male meiocytes at diakinesis stained for DAPI and immunostained for MLH1 (green) in
wild type and kyp suvh5 suvh6. Bivalent chromosomes are evident that are associated with …
wild type and kyp suvh5 suvh6. Bivalent chromosomes are evident that are associated with …
DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis
… 3C). This is consistent with methylated regions showing higher nucleosome occupancy in
Arabidopsis (Chodavarapu et al. 2010). Together, these data demonstrate that establishment …
Arabidopsis (Chodavarapu et al. 2010). Together, these data demonstrate that establishment …
Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis
During meiosis, homologous chromosomes undergo reciprocal crossovers, which generate
genetic diversity and underpin classical crop improvement. Meiotic recombination initiates …
genetic diversity and underpin classical crop improvement. Meiotic recombination initiates …