User profiles for C. Lambing

Christophe Lambing

Group Leader, Rothamsted Research
Verified email at rothamsted.ac.uk
Cited by 2095

Understanding and manipulating meiotic recombination in plants

C Lambing, FCH Franklin, CJR Wang - Plant physiology, 2017 - academic.oup.com
… For example, a change in temperature from 22C to 30C caused a reduction in chiasmata
and seed set in barley. However, the distribution of COs was altered, and there were …

Role of RANK ligand and denosumab, a targeted RANK ligand inhibitor, in bone health and osteoporosis: a review of preclinical and clinical data

DW Dempster, CL Lambing, PJ Kostenuik, A Grauer - Clinical therapeutics, 2012 - Elsevier
… Transition to denosumab also produced significantly greater reductions in bone turnover
markers compared with continued alendronate (serum C-telopeptide and intact NTX, specific …

The genetic and epigenetic landscape of the Arabidopsis centromeres

…, A Schmücker, T Mandáková, B Jamge, C Lambing… - Science, 2021 - science.org
INTRODUCTION The centromeres of eukaryotic chromosomes assemble the multiprotein
kinetochore complex and thereby position attachment to the spindle microtubules, allowing …

[HTML][HTML] Rewiring meiosis for crop improvement

P Kuo, O Da Ines, C Lambing - Frontiers in Plant Science, 2021 - frontiersin.org
… (B,C) Non-reductional meiotic divisions resulting in unreduced (2n) meiotic products. First
division restitution (FDR; B) and second division restitution (SDR; C) lead to different levels of …

Nucleosomes and DNA methylation shape meiotic DSB frequency in Arabidopsis thaliana transposons and gene regulatory regions

K Choi, X Zhao, AJ Tock, C Lambing… - Genome …, 2018 - genome.cshlp.org
… We generated a 6×Myc translational fusion at the C terminus of A. thaliana SPO11-1, driven
by the endogenous promoter, which fully complements spo11-1 infertility and crossover …

[HTML][HTML] Inter-Homolog Crossing-Over and Synapsis in Arabidopsis Meiosis Are Dependent on the Chromosome Axis Protein AtASY3

M Ferdous, JD Higgins, K Osman, C Lambing… - PLoS …, 2012 - journals.plos.org
In this study we have analysed AtASY3, a coiled-coil domain protein that is required for
normal meiosis in Arabidopsis. Analysis of an Atasy3-1 mutant reveals that loss of the protein …

Natural variation and dosage of the HEI10 meiotic E3 ligase control Arabidopsis crossover recombination

PA Ziolkowski, CJ Underwood, C Lambing… - Genes & …, 2017 - genesdev.cshlp.org
… Therefore, we postulate that the HEI10 C-terminal R264 variant may alter substrate
recognition efficiency and SUMO/ubiquitin transfer during regulation of meiotic recombination. …

Epigenetic activation of meiotic recombination near Arabidopsis thaliana centromeres via loss of H3K9me2 and non-CG DNA methylation

CJ Underwood, K Choi, C Lambing, X Zhao… - Genome …, 2018 - genome.cshlp.org
… (C) Male meiocytes at diakinesis stained for DAPI and immunostained for MLH1 (green) in
wild type and kyp suvh5 suvh6. Bivalent chromosomes are evident that are associated with …

DNA methylation epigenetically silences crossover hot spots and controls chromosomal domains of meiotic recombination in Arabidopsis

NE Yelina, C Lambing, TJ Hardcastle… - Genes & …, 2015 - genesdev.cshlp.org
… 3C). This is consistent with methylated regions showing higher nucleosome occupancy in
Arabidopsis (Chodavarapu et al. 2010). Together, these data demonstrate that establishment …

Massive crossover elevation via combination of HEI10 and recq4a recq4b during Arabidopsis meiosis

H Serra, C Lambing, CH Griffin… - Proceedings of the …, 2018 - National Acad Sciences
During meiosis, homologous chromosomes undergo reciprocal crossovers, which generate
genetic diversity and underpin classical crop improvement. Meiotic recombination initiates …