[HTML][HTML] Microglial implication in Parkinson's disease: loss of beneficial physiological roles or gain of inflammatory functions?

C Lecours, M Bordeleau, L Cantin, M Parent… - Frontiers in Cellular …, 2018 - frontiersin.org
Microglia, often described as the brain-resident macrophages, play crucial roles in central
nervous system development, maintenance, plasticity, and adaptation to the environment. …

[HTML][HTML] From the Cajal alumni Achúcarro and Río-Hortega to the rediscovery of never-resting microglia

MÈ Tremblay, C Lecours, L Samson… - Frontiers in …, 2015 - frontiersin.org
… Río-Hortega continued the work of Achucarro and in 1919 developed his silver carbonate
method, finally enabling him to resolve microglia (C) from what he initially called interfascicular …

Dark microglia: a new phenotype predominantly associated with pathological states

K Bisht, KP Sharma, C Lecours, M Gabriela Sánchez… - Glia, 2016 - Wiley Online Library
… The animals were housed under a 12-h light–dark cycle at 22C–25C with free access to …
Briefly, the sections were blocked and incubated overnight at 4 C in primary antibody solution, …

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

G Milior, C Lecours, L Samson, K Bisht… - Brain, behavior, and …, 2016 - Elsevier
… All samples were kept on ice and later centrifuged at 3000 rpm for 15 min at 4 C. Blood
plasma was transferred to Eppendorf tubes for corticosterone determination and stored at −80 C

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo

…, F Jolivette, C Lecours, K Bisht, C Goupil… - Human molecular …, 2015 - academic.oup.com
… 2C and D), consistent with our previous observations (40). Tau mRNA remained unchanged
… 3A and C). This effect was specific for endogenous mouse tau, as human tau remained …

[HTML][HTML] Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the mouse developing brain

…, A Aubert, V De Smedt-Peyrusse, C Lecours… - Nature …, 2020 - nature.com
Omega-3 fatty acids (n-3 PUFAs) are essential for the functional maturation of the brain.
Westernization of dietary habits in both developed and developing countries is accompanied by …

Freestyle pedicle perforator flaps: clinical results and vascular anatomy

C Lecours, M Saint-Cyr, C Wong… - Plastic and …, 2010 - journals.lww.com
Background: Perforator flaps have increased in use, with advantages such as sparing of the
underlying muscle with resultant decreased donor-site morbidity and the possibility of …

Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment

…, S Garofalo, G Milior, H El Hajj, C Lecours… - Brain, behavior, and …, 2016 - Elsevier
… were: 95 C 10 min and 95 C 15 s, 60 C 1 min for 40 cycles. Single PCR products were
subjected to a heat dissociation (gradual increase of temperature from 60 C to 95 C) and agarose …

[HTML][HTML] Remodeling of lipid bodies by docosahexaenoic acid in activated microglial cells

…, I Zhang, K Bisht, JC Savage, C Lecours… - Journal of …, 2016 - Springer
Background Organelle remodeling processes are evolutionarily conserved and involved in
cell functions during development, aging, and cell death. Some endogenous and exogenous …

[HTML][HTML] Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctions

…, M Lavoie, JJ Leclerc, T Lecomte, C Lecours… - … Psychiatry Global Open …, 2024 - Elsevier
… (C) Chart describing the jejunum tight junction features and parameters analyzed. (D) t-SNE
visualization of the k-means clustering. The 4 features (ruffle quantity, width, fragmentation, …