… When introducing and developing novel drug discovery technologies in general, the response
of the scientific and business communities has often been similar (C. Lipinski, personal …

… 3 cos 2 θ MHN −1 2 4τ c + 3τ c 1+ω I 2 τ c 2 . The angle θ MHN is that between the HN axis
and the H-metal axis, r is the H-metal distance and τ c is the correlation time modulating both …

… Indeed, several applications of 13 C direct detection to … to the C β through a CBCACO
experiment, while the C α is connected to the remaining atoms of the side chain though a 13 C-…

… Koenig at a later stage was important for both Ivano Bertini and Claudio Luchinat. A special
role in our understanding of the intricacies of paramagnetic shifts and relaxation has been …

… 1.5 mm 13 C-optimized probe based on HTS coil technology, which provides over twice
the mass sensitivity of any commercial 13 C-optimized probe; this makes it ideal for 13 C-based …

… that is an intermediate metabolite of glycolysis: in plasma it is slightly decreasing/constant
at 4C and it increases at 25C; in serum, it decreases at 4C and is almost constant at 25…

Many diseases cause significant changes to the concentrations of small molecules (aka
metabolites) that appear in a person’s biofluids, which means such diseases can often be …

… The quality of the spectra permits, while operating at relatively high magnetic field (16.4–20.0
T) as used in this work, the 2D 13 C– 13 C correlation maps to be well resolved. It is worth …

… Sonicate and ultra-centrifugate for 1 h at 4 C. Collect the supernatant in sterile condition …
Refrigerated automatic sample changers, where NMR tubes are kept at 6 C until acquisition, …

… 5c). Such spectra may be viewed as representing an image of the individual metabolic
fingerprint (somewhat related to “metabotype”) and by which it is possible to assess easily, even …