Studies were conducted with the final goal of identifying genes of interest mapping to the
chromosome region 16q23.3–24.1, an area commonly affected by allelic losses in breast …

We recently reported the cloning of WWOX, a gene that maps to the common fragile site
FRA16D region in chromosome 16q23.3-24.1. It was observed that the genomic area spanned …

Motivation: In contrasting levels of gene expression between groups of SAGE libraries, the
libraries within each group are often combined and the counts for the tag of interest summed, …

Arginine methylation has been implicated in the regulation of gene expression. The
coactivator-associated arginine methyltransferase 1 (CARM1/PRMT4) binds the p160 family of …

Aberrations affecting the tumor suppressor gene p16 INK4a have been described for a variety
of tumors. In breast cancer, approximately 50% of tumors show low or lack p16 expression…

The majority of estrogen receptor (ER)-positive breast cancers are treated with endocrine
therapy. While this is effective, acquired resistance to therapies targeted against ER is a major …

The important role played by the sex hormone estrogen in disease and physiological
processes has been well documented. However, the mechanisms by which this hormone elicits …

By crossing mice that carry a null allele of p53 with transgenic mice that develop mammary
adenocarcinomas under the influence of a Wnt-1 transgene, we have studied the …

Global gene expression measured by DNA microarray platforms have been extensively
used to classify breast carcinomas correlating with clinical characteristics, including outcome. …

Introduction Genomic and transcriptomic alterations affecting key cellular processes such us
cell proliferation, differentiation and genomic stability are considered crucial for the …