… The reaction was allowed to progress at 25C for 1 hour. The reaction was then stopped by …
for 20 minutes at 4C. Supernatants were then removed for subsequent Western blot analyses. …

Rats were subjected to either right proximal middle cerebral artery (MCA) occlusion or sham
operation, and examined for an extendend period on a battery of tests designed to measure …

… Remarkably, in the present study Markgraf and coworkers demonstrated a 6-hour therapeutic
window for calpain inhibition in a rat model of focal stroke. Although MDL 28,170 is a …

The kinase-activating mutation G2019S in leucine-rich repeat kinase 2 (LRRK2) is one of the
most common genetic causes of Parkinson’s disease (PD) and has spurred development …

… In the model describedby Markgraf et althe differences inthe volume of the brain lesions … in
Wistar rats the brain lesion (induced by the Markgraf method) does not fully mature until 3 or 4 …

Object. The goal of this study was to evaluate the therapeutic window for hypothermia
treatment following experimental brain injury by measuring edema formation and functional …

… Survey topics included (a) an update on ICH S7A and S7B practices, (b) frontloading Safety
Pharmacology studies prior to selection of candidate drugs, (c) abuse and dependence-…

The Safety Pharmacology Society (SPS) conducted an industry survey in 2015 to identify
industry practices as they relate to central, peripheral and autonomic nervous system (‘CNS’) …

… C) to improve outcome following severe traumatic brain injury in humans. The current
study examined whether hypothermia (32C) … Ten of the injured rats were cooled to 32C (measured …

… Animals were subjected to 12.5 min of four vessel occlusion (4VO) with moderate hypotension,
and brain temperature maintained at either 37C (4VO-37) or 30C (4VO-30). Behavioral …