… Aside from one large kindred with a mutation in the gene encoding surfactant protein C in
affected family members, the genetic basis of familial forms of idiopathic pulmonary fibrosis is …

Background The mutations that have been implicated in pulmonary fibrosis account for only
a small proportion of the population risk. Methods Using a genomewide linkage scan, we …

We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic
idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up …

… To demonstrate pro-SP-C expression by these type II AECs, we performed IHC for pro-SP-C
on lung tissue from individuals with UIP in the presence or absence of an L188Q SFTPC …

… to calculate 95% confidence intervals for the C statistic within each cohort. We used a
permutation test to assess the difference between C statistic values for the nested models in each …

Fiberoptic bronchoscopy is an important tool in diagnosing and managing various pulmonary
conditions in critically ill patients. An understanding of the materials and equipment …

… Mutations in the surfactant protein C (SP-C) gene (SFTPC) are associated with familial … and
may hinder processing of SP-C precursor protein. SP-C precursor protein displayed aberrant …

Discussion Lipoid pneumonia is a rare, primarily chronic inflammatory reaction secondary
to the presence of lipid substances in the lungs, with subsequent uptake by alveolar …

… C but 260-fold less activity when it was expressed at 37C (table S6 and fig. S39), suggesting
that >99% of the 37C-… WT PafA exhibits identical CD spectra when expressed at 37 or 23C; …

… Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial
pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit …