… (C) A model for transcriptional activation by c-Myc. Once bound to DNA as a heterodimer
with Max, Myc can recruit HAT complexes (such as SAGA) which contain the ATM family …

… Class III HLH proteins contain myc related proteins, each of them involved in growth control,
including c-myc, N-myc and L-myc [16]. Recently, new HLH members have been identified …

Helix-loop-helix (HLH) proteins are transcriptional regulators that control a wide variety of
developmental pathways in both invertebrate and vertebrate organisms. Results obtained in …

… for C/EBPa and C/EBPb in peritoneal macrophages and for Oct-2 in splenic B cells. For C/EBPa
and C/… $40,000 binding sites (Table S1 and Figure S2C). Of these sites, 13,840 (34.6%) …

… T3 The ability of AS-C T3 to bind to KEY as a heterodimer with El2 and E47S suggests that
… with da (Murre et al., 1989). Therefore we tested the ability of da and AS-C T3 products to …

… The recombinant did not bind to either a pE3 or a uE4 trimerized probe (C. Murre and D. …
uE5 (TGCAGGTGT), a site that is identical to KEY in its core sequences, did compete (C. …

El2 and E47 are two helix-loop-helix transcription factors that arise by alternative splicing of
the E2A gene. Both have been implicated in the regulation of immunoglobulin gene …

In this report we provide four lines of evidence indicating that El2/E47-like proteins interact in
vivo with the myogenic HLH proteins MyoDand myogenin. First, cotransfection of MyoD and …

… A large number of proteins containing the helix-loop-helix DNA binding and dimerization
motif have been recognized recently (Murre et al., 1989a, 1989b). One set of these, encoded by …

It is now established that the transcription factors E2A, EBF1 and Foxo1 have critical roles in
B cell development. Here we show that E2A and EBF1 bound regulatory elements present …