Background There are few epidemiologic data on invasive bacterial infections among
children in sub-Saharan Africa. We studied every acute pediatric admission to a rural district …

Background Point of-care (POC) HIV-1 RNA tests which are accurate and easy to use with
limited infrastructure are needed in resource-limited settings (RLS). We systematically …

Background Estimates of the burden of invasive bacterial disease in sub-Saharan Africa
have previously relied on selected groups of patients, such as inpatients; they are, therefore, …

… Among those with an axillary temperature ≥ 39C but without a defined syndromic indication
for antibiotics, an accurate malaria slide may be helpful in deciding on antibiotic treatment: 1 …

… Brett Lowe, Caroline Ngetsa, and Salim Mwarumba were responsible for laboratory analysis
and data collection. James Berkley, Isiah Mwangi, and Charles Newton were responsible …

Malaria and iron deficiency (ID) are common and interrelated public health problems in African
children. Observational data suggest that interrupting malaria transmission reduces the …

Background Recently, we found that a new malaria vaccine, R21/Matrix-M, had over 75%
efficacy against clinical malaria with seasonal administration in a phase 2b trial in Burkina Faso…

Background Africa has the highest incidence of gonorrhea in the world. However, little is
known about gonococcal populations in this continent or mechanisms of antimicrobial …

Background Many parts of Africa have witnessed reductions in Plasmodium falciparum
transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher …

Severe falciparum malaria has substantially affected human evolution. Genetic association
studies of patients with clinically defined severe malaria and matched population controls …