[HTML][HTML] Regulation of JNK signaling by GSTp
…, MR Pincus, M Sardana, CJ Henderson, CR Wolf… - The EMBO …, 1999 - embopress.org
Studies of low basal Jun N‐terminal kinase (JNK) activity in non‐stressed cells led us to
identify a JNK inhibitor that was purified and identified as glutathione S‐transferase Pi (GSTp) …
identify a JNK inhibitor that was purified and identified as glutathione S‐transferase Pi (GSTp) …
Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer.
…, MJ Stubbins, D Forman, GC Howard, CR Wolf - …, 1997 - academic.oup.com
… at 94C for 5 min followed by 20 cycles of denaturation at 94C for 30 s, primer annealing at
47C for 60 s and polymerization at 72C for … at 94C for 30 s and polymerization at 72C for 60 s. …
47C for 60 s and polymerization at 72C for … at 94C for 30 s and polymerization at 72C for 60 s. …
The Cap 'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal …
…, CJ Henderson, LI McLellan, CR Wolf, C Cavin… - Cancer research, 2001 - AACR
Northern blotting has shown that mouse small intestine contains relatively large amounts of
the nuclear factor-E2 p45-related factor (Nrf) 2 transcription factor but relatively little Nrf1. …
the nuclear factor-E2 p45-related factor (Nrf) 2 transcription factor but relatively little Nrf1. …
Mutations in APC, Kirsten-ras, and p53—alternative genetic pathways to colorectal cancer
…, RC Garner, RJC Steele, CR Wolf - Proceedings of the …, 2002 - National Acad Sciences
Colorectal cancer is one of the most significant causes of cancer death. A genetic model for
colorectal cancer has been proposed in which the sequential accumulation of mutations in …
colorectal cancer has been proposed in which the sequential accumulation of mutations in …
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
MD Burke, S Thompson, RJ Weaver, CR Wolf… - Biochemical …, 1994 - Elsevier
The O-dealkylations of ethoxyresorufin and pentoxyresorufin are widely used activity probes
for measuring the cytochrome P450 forms, CYP1A1 and CYP2B1, respectively, and their …
for measuring the cytochrome P450 forms, CYP1A1 and CYP2B1, respectively, and their …
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2 …
…, CR Elcombe, CJ Henderson, CR Wolf… - Biochemical …, 2002 - portlandpress.com
Mice that lack the Nrf2 basic-region leucine-zipper transcription factor are more sensitive
than wild-type (WT) animals to the cytotoxic and genotoxic effects of foreign chemicals and …
than wild-type (WT) animals to the cytotoxic and genotoxic effects of foreign chemicals and …
Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.
…, A Hewer, DH Phillips, LW Harries, CR Wolf… - …, 1997 - academic.oup.com
The AG polymorphism at codon 104 in the glutathione S-transferase P1 (GSTP1) gene was
examined in 138 male lung cancer patients and 297 healthy controls. The patients had …
examined in 138 male lung cancer patients and 297 healthy controls. The patients had …
Feedback control of AHR signalling regulates intestinal immunity
…, Y Li, AJ Potocnik, S Omenetti, CJ Henderson, CR Wolf… - Nature, 2017 - nature.com
The aryl hydrocarbon receptor (AHR) recognizes xenobiotics as well as natural compounds
such as tryptophan metabolites, dietary components and microbiota-derived factors 1 , 2 , 3 , …
such as tryptophan metabolites, dietary components and microbiota-derived factors 1 , 2 , 3 , …
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases
…, J Ure, K Brown, EJ Bacon, CR Wolf - Proceedings of the …, 1998 - National Acad Sciences
The activity of chemical carcinogens is a complex balance between metabolic activation by
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S-…
cytochrome P450 monooxygenases and detoxification by enzymes such as glutathione S-…
Identification of the primary gene defect at the cytochrome P450CYP2D locus
…, JE Moss, A Gaedigk, M Eichelbaum, CR Wolf - Nature, 1990 - nature.com
THE mammalian cytochrome P 450 -dependent monooxygenase system is involved in the
metabolism of drugs and chemical carcinogens 1–5 . The role of these enzymes in …
metabolism of drugs and chemical carcinogens 1–5 . The role of these enzymes in …