Synaptic distributions of GluA2 and PKMζ in the monkey dentate gyrus and their relationships with aging and memory
Rhesus monkeys provide a valuable model for studying the neurobiological basis of cognitive
aging, because they are vulnerable to age-related memory decline in a manner similar to …
aging, because they are vulnerable to age-related memory decline in a manner similar to …
Synaptic correlates of memory and menopause in the hippocampal dentate gyrus in rhesus monkeys
Aged rhesus monkeys exhibit deficits in hippocampus-dependent memory, similar to aging
humans. Here we explored the basis of cognitive decline by first testing young adult and …
humans. Here we explored the basis of cognitive decline by first testing young adult and …
Cardiovascular pharmacogenomics: does it matter if you're black or white?
Race and ancestry have long been associated with differential risk and outcomes to disease
as well as responses to medications. These differences in drug response are multifactorial …
as well as responses to medications. These differences in drug response are multifactorial …
[HTML][HTML] Genome-wide analysis of H4K5 acetylation associated with fear memory in mice
Background Histone acetylation has been implicated in learning and memory in the brain,
however, its function at the level of the genome and at individual genetic loci remains poorly …
however, its function at the level of the genome and at individual genetic loci remains poorly …
Synaptic characteristics of dentate gyrus axonal boutons and their relationships with aging, menopause, and memory in female rhesus monkeys
Age-related memory impairment occurs in many mammalian species, including humans.
Moreover, women undergoing the menopausal transition often complain of problems with …
Moreover, women undergoing the menopausal transition often complain of problems with …
[HTML][HTML] Discovery of novel hepatocyte eQTLs in African Americans
African Americans (AAs) are disproportionately affected by metabolic diseases and adverse
drug events, with limited publicly available genomic and transcriptomic data to advance the …
drug events, with limited publicly available genomic and transcriptomic data to advance the …
α-Isoform of calcium-calmodulin-dependent protein kinase II and postsynaptic density protein 95 differentially regulate synaptic expression of NR2A–and NR2B …
N-methyl-d-aspartate receptors (NMDARs) are critical determinants of bidirectional synaptic
plasticity, however, studies of NMDAR function have been based primarily on …
plasticity, however, studies of NMDAR function have been based primarily on …
Differences in the platelet mRNA landscape portend racial disparities in platelet function and suggest novel therapeutic targets
The African American (AA) population displays a 1.6 to 3‐fold higher incidence of thrombosis
and stroke mortality compared with European Americans (EAs). Current antiplatelet …
and stroke mortality compared with European Americans (EAs). Current antiplatelet …
Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake
M Seimandi, P Seyer, CS Park… - Journal of …, 2013 - Soc Neuroscience
Homeostasis of serotonergic transmission critically depends on the rate of serotonin reuptake
via its plasma membrane transporter (SERT). SERT activity is tightly regulated by multiple …
via its plasma membrane transporter (SERT). SERT activity is tightly regulated by multiple …
Protein phosphatases in the brain: regulation, function and disease
… C. Sehwan Park & … It consists of an A-subunit with an N-terminal catalytic domain, a C-terminal
regulatory region containing binding sites for the PP2B B-subunit and calmodulin, and an …
regulatory region containing binding sites for the PP2B B-subunit and calmodulin, and an …