… Lithium dose is best decreased by half or held for some days in cases with fever above 38
C (100.4 F), dehydration or diarrhea. Lithium also should be taken with extra caution during …

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Background Environmental conditions early in life may imprint the circadian system and
influence response to environmental signals later in life. We previously determined that a large …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …

Clinical research centers in Aarhus, Berlin, Hamilton and Vienna collected mortality data for
827 manic‐depressive and schizoaffective patients given lithium treatment for more than 6 …

Importance Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder
(BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%…

The mortality of patients suffering from affective disorders is much higher than that of the
general population; this excess is due to both suicides and cardiovascular disease. During long-…

A multicenter randomized 4-week interindividual double-blind study was carried out in 58
hospitalized patients with major depressive disorder (DSM III 296.23,296.22,296.33,296.32,…

BackgroundNeuroimaging studies have demonstrated an association between lithium (Li)
treatment and brain structure in human subjects. A crucial unresolved question is whether this …