Over the past 15 years there has been remarkable progress in the specification and estimation
of dynamic stochastic general equilibrium (DSGE) models. Central banks in developed …

The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a
transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is …

Aim Climate change is expected to impact mountain biodiversity by shifting species ranges
and the biomes they shape. The extent and regional variation in these impacts are still poorly …

The p53 tumor suppressor retains its wild-type conformation and transcriptional activity in
half of all human tumors, and its activation may offer a therapeutic benefit. However, p53 …

CDK1 is a nonredundant cyclin-dependent kinase (CDK) with an essential role in mitosis,
but its multiple functions still are poorly understood at a molecular level. Here we identify a …

… − T 0 )/(C − C 0 )], in which T and C represent mean tumor volume on a specific day during
the experiment of a treated group and the vehicle control group, respectively, and T 0 and C 0 …

Risk management has reduced vulnerability to floods and droughts globally 1 , 2 , yet their
impacts are still increasing 3 . An improved understanding of the causes of changing impacts …

Restoration of p53 activity by inhibition of the p53–MDM2 interaction has been considered
an attractive approach for cancer treatment. However, the hydrophobic protein–protein …

… A fascicle of axons (block arrow, C) is next to several macrophages (open block arrows, C).
The macrophages in D are from the lesion center at 5 days and contain many more dense …

The p53 tumor suppressor is a potent transcription factor that plays a key role in the regulation
of cellular responses to stress. It is controlled by its negative regulator MDM2, which binds …