Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

…, AH Skogholt, JA Smith, AE Taylor, C Turman… - Nature …, 2019 - nature.com
Tobacco and alcohol use are leading causes of mortality that influence risk for many complex
diseases and disorders 1 . They are heritable 2 , 3 and etiologically related 4 , 5 behaviors …

The power of genetic diversity in genome-wide association studies of lipids

…, A Rasheed, JD Faul, W Zhao, DR Weir, C Turman… - Nature, 2021 - nature.com
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied
prevalence worldwide owing to different dietary patterns and medication use 1 . Despite …

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

…, P Kraft, DJ Hunter, KL Penney, C Turman… - Nature …, 2021 - nature.com
Prostate cancer is a highly heritable disease with large disparities in incidence rates across
ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer …

[HTML][HTML] Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

…, HM Stringham, T Tanaka, A Teumer, C Turman… - Nature …, 2022 - nature.com
Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions

…, PL Møller, L Stefansdottir, G Galarneau, C Turman… - Nature …, 2023 - nature.com
Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

[HTML][HTML] A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts

S Lindström, S Loomis, C Turman, H Huang, J Huang… - PloS one, 2017 - journals.plos.org
… We flipped strands where appropriate and removed A/T and C/G SNPs to create the final …
C: QQ-plot for GWAS analysis of body mass index on the Illumina HumanHap platform (n = …

Antidepressant‐induced mania: an overview of current controversies

JF Goldberg, CJ Truman - Bipolar disorders, 2003 - Wiley Online Library
Objective: The prevalence, characteristics, and possible risk factors associated with
antidepressant‐induced mania remain poorly described. The present review sought to identify …

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

…, C Barbieri, A Cavadino, JE Chavarro, C Turman… - Nature …, 2016 - nature.com
The genetic architecture of human reproductive behavior—age at first birth (AFB) and number
of children ever born (NEB)—has a strong relationship with fitness, human development, …

The Mediterranean diet, plasma metabolome, and cardiovascular disease risk

…, FK Tabung, J Hu, T Zhao, C Turman… - European heart …, 2020 - academic.oup.com
… The correlations between MEDAS and the 67-metabolite signature in the two validation
sets are shown in (C) and (D). In the training set, in order to include the training dataset in …

[HTML][HTML] Identification of nine new susceptibility loci for endometrial cancer

…, J Trovik, C Turman, JP Tyrer, C Vachon… - Nature …, 2018 - nature.com
Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract
in developed countries. Through genome-wide association studies (GWAS), we have …