… the bottom generation can be inferred by comparing the haplotypes they inherited with copies
of the same haplotypes that are IBD and present in other individuals in the family (panel c). …

… ’s LDL-C PRS; that is, those with a low LDL-C PRS and monogenic FH had, on average,
lower LDL-C and a lower risk of CAD compared with those with a high LDL-C PRS and …

Spatial management, including setting aside conservation areas, is central to curbing the
global decline of biodiversity, but many threats originate from beyond the boundaries of …

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

To identify common variants influencing body mass index (BMI), we analyzed genome-wide
association data from 16,876 individuals of European descent. After previously reported …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …