Hydrogen peroxide-mediated oxidative stress disrupts calcium binding on calmodulin: more evidence for oxidative stress in vitiligo

KU Schallreuter, NCJ Gibbons, C Zothner… - Biochemical and …, 2007 - Elsevier
Patients with acute vitiligo have low epidermal catalase expression/activities and accumulate
10 −3 MH 2 O 2 . One consequence of this severe oxidative stress is an altered calcium …

[HTML][HTML] Evaluation of a range of mammalian and mosquito cell lines for use in Chikungunya virus research

GC Roberts, C Zothner, R Remenyi, A Merits… - Scientific reports, 2017 - nature.com
Chikungunya virus (CHIKV) is becoming an increasing global health issue which has spread
across the globe and as far north as southern Europe. There is currently no vaccine or anti-…

[HTML][HTML] Methionine sulfoxide reductases A and B are deactivated by hydrogen peroxide (H2O2) in the epidermis of patients with vitiligo

…, DJ Maitland, B Chavan, C Zothner… - Journal of investigative …, 2008 - Elsevier
… 2a) due to the methylene protons on C-4 with at proton ratio of 1:2:1 clearly confirms the
presence of two diastereomers. H- 1 H COSY and 1 H- 13 C HMQC spectra confirmed that the …

[HTML][HTML] Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry

…, MN Batista, AC Nazaré, CR Polaquini, C Zothner… - Scientific reports, 2017 - nature.com
Hepatitis C virus (HCV) is one of the leading causes of liver diseases and transplantation
worldwide. The current available therapy for HCV infection is based on interferon-α, ribavirin …

[HTML][HTML] Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging

…, RJ Bingham, SJ White, EC Dykeman, C Zothner… - Scientific reports, 2016 - nature.com
The specific packaging of the hepatitis C virus (HCV) genome is hypothesised to be driven by
Core-RNA interactions. To identify the regions of the viral genome involved in this process, …

[HTML][HTML] Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?

…, DOS Martins, MJ McPhillie, GC Roberts, C Zothner… - Acta tropica, 2020 - Elsevier
Chikungunya virus (CHIKV) is a mosquito-transmitted virus of special concern as it causes
Chikungunya fever, characterized by an acute febrile illness, rash, and arthralgia that can …

Persistent replication of a chikungunya virus replicon in human cells is associated with presence of stable cytoplasmic granules containing nonstructural protein 3

…, Y Gao, RE Hughes, A Curd, C Zothner… - Journal of …, 2018 - Am Soc Microbiol
Chikungunya virus (CHIKV), a mosquito-borne human pathogen, causes a disabling disease
characterized by severe joint pain that can persist for weeks, months, or even years in …

[HTML][HTML] Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle

…, GRF Campos, S da Silva, ACO Cintra, C Zothner… - PLoS …, 2017 - journals.plos.org
Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide.
Current therapy is expensive, presents additional side effects and viral resistance has …

[HTML][HTML] SNAP-tagged chikungunya virus replicons improve visualisation of non-structural protein 3 by fluorescence microscopy

R Remenyi, GC Roberts, C Zothner, A Merits… - Scientific Reports, 2017 - nature.com
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes febrile disease, muscle
and joint pain, which can become chronic in some individuals. The non-structural protein 3 (…

Recombinant human L-ficolin directly neutralizes hepatitis C virus entry

MR Hamed, RJP Brown, C Zothner… - Journal of innate …, 2014 - karger.com
L-ficolin is a soluble pattern recognition molecule expressed by the liver that contributes to
innate immune defense against microorganisms. It is well described that binding of L-ficolin to …