Ewing sarcoma family tumors (ESFT) are aggressive bone and soft tissue tumors that
express EWS-ETS fusion genes as driver mutations. Although the histogenesis of ESFT is …

The polycomb proteins BMI-1 and EZH2 are highly overexpressed by Ewing sarcoma (ES), a
tumor of stem cell origin that is driven by EWS-ETS fusion oncogenes, most commonly EWS…

… RN Fonseca, C. von Levetzow, and M. Van der Zee are members of the International
Graduate School in Genetics and Functional Genomics, Cologne. This project is part of DFG …

Purpose An increasing number of international studies demonstrate serious negative effects
of the COVID-19 pandemic on the timely diagnosis of cancer and on cancer treatment. Our …

10.7554/eLife.47346.001 The Drosophila Fog pathway represents one of the best-understood
signaling cascades controlling epithelial morphogenesis. During gastrulation, Fog …

The gene regulatory network controlling dorsoventral axis formation in insects has undergone
drastic evolutionary changes. In Drosophila, a stable long-range gradient of Toll signalling …

… C: Pie chart showing the distribution of potential targets occurring beside the MAP2K1 … 3C
summarizes the potential therapeutic targets in MAP2K1-mutated NSCLC patients. Besides …

… 4C displays the distribution of TPSs by expression group. In the group of patients with
ROS1 +/- TP53 mutations (ie without additional co-mutations) the median PD-L1 TPS was 2 (…

Bone morphogenetic protein (BMP) signaling plays a major role in dorsoventral patterning in
vertebrates and in Drosophila. Remarkably, in Tribolium, a beetle with an ancestral type of …

Chronic myeloid leukemia (CML) is induced by BCR-ABL1 and can be effectively treated for
many years with Imatinib until leukemia cells acquire drug resistance through BCR-ABL1 …