Transcription factors (TFs) direct gene expression by binding to DNA regulatory regions. To
explore the evolution of gene regulation, we used chromatin immunoprecipitation with high-…

CYP3A4 is the most abundantly expressed drug-metabolizing P450 enzyme in human liver
and contributes to the metabolism of a large number of drugs in use today. CYP3A4 is …

Aging is characterized by progressive loss of physiological and cellular functions, but the
molecular basis of this decline remains unclear. We explored how aging affects transcriptional …

Male gametes are generated through a specialised differentiation pathway involving a series
of developmental transitions that are poorly characterised at the molecular level. Here, we …

Adaptation of liver to nutritional signals is regulated by several transcription factors that are
modulated by intracellular metabolites. Here, we demonstrate a transcription factor network …

The bone marrow in the skull is important for shaping immune responses in the brain and
meninges, but its molecular makeup among bones and relevance in human diseases remain …

Single-cell RNA-seq reveals the role of pathogenic cell populations in development and
progression of chronic diseases. In order to expand our knowledge on cellular heterogeneity, …

Hepatocyte nuclear factor 4α (HNF4α) is a key transcription factor for the constitutive
expression of cytochromes P450 (P450s) in the liver. However, human hepatoma HepG2 cells …

How the age‐associated decline of immune function leads to increased cancer incidence is
poorly understood. Here, we have characterised the cellular composition of the γδ T‐cell …

Introduction For the optimal management of children with cystic fibrosis, there are currently
no efficient tools for the precise adjustment of pancreatic enzyme replacement therapy, either …