User profiles for CA Fogarty

Carl A. Fogarty

PhD Candidate, Maynooth University.
Verified email at mumail.ie
Cited by 1253

Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein

…, AC Dommer, AM Harbison, CA Fogarty… - ACS central …, 2020 - ACS Publications
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 deaths …

[HTML][HTML] The case for post-predictional modifications in the AlphaFold Protein Structure Database

H Bagdonas, CA Fogarty, E Fadda… - Nature structural & …, 2021 - nature.com
To the editor—AlphaFold2 has arrived to change workflows in structural biology, for good.
However, the algorithm does not account for essential modifications that affect protein …

[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics

ML Newby, CA Fogarty, JD Allen, J Butler… - Journal of Molecular …, 2023 - Elsevier
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists in …

[HTML][HTML] Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S

AM Harbison, CA Fogarty, TK Phung, A Satheesan… - Chemical …, 2022 - pubs.rsc.org
The dense glycan shield is an essential feature of the SARS-CoV-2 spike (S) architecture,
key to immune evasion and to the activation of the prefusion conformation. Recent studies …

[PDF][PDF] Citizen scientists create an exascale computer to combat COVID-19

…, RP Wiewiora, MFD Hurley, AM Harbison, CA Fogarty… - BioRxiv, 2020 - scienceopen.com
The SARS-CoV-2/COVID-19 pandemic continues to threaten global health and socioeconomic
stability. Experiments have revealed snapshots of many of the viral components but …

[HTML][HTML] SARS-CoV-2 simulations go exascale to capture spike opening and reveal cryptic pockets across the proteome

…, RP Wiewiora, MFD Hurley, AM Harbison, CA Fogarty… - BioRxiv, 2020 - ncbi.nlm.nih.gov
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression,
and replication, which depend on the structure and dynamics of its constituent proteins. …

[HTML][HTML] How and why plants and human N-glycans are different: Insight from molecular dynamics into the “glycoblocks” architecture of complex carbohydrates

CA Fogarty, AM Harbison… - Beilstein journal of …, 2020 - beilstein-journals.org
The N-glycosylation is one of the most abundant and diverse post-translational modifications
of proteins, implicated in protein folding and structural stability, and mediating interactions …

Obstetrics and gynecology—to be or not to be? Factors influencing one's decision

CA Fogarty, RG Bonebrake, AD Fleming… - American journal of …, 2003 - Elsevier
OBJECTIVE: The study was undertaken to determine factors influencing a medical student's
decision to choose obstetrics and gynecology (OB/GYN) versus another specialty. STUDY …

Restoring Protein Glycosylation with GlycoShape

CM Ives, O Singh, S D'Andrea, CA Fogarty… - bioRxiv, 2023 - biorxiv.org
During the past few years we have been witnessing a revolution in structural biology.
Leveraging on technological and computational advances, scientists can now resolve …

Oligomannose N-Glycans 3D Architecture and Its Response to the FcγRIIIa Structural Landscape

CA Fogarty, E Fadda - The Journal of Physical Chemistry B, 2021 - ACS Publications
Oligomannoses are evolutionarily the oldest class of N-glycans, where the arms of the
common pentasaccharide unit, ie, Manα(1–6)-[Manα(1–3)]-Manβ(1–4)-GlcNAcβ(1–4)-GlcNAcβ1-…