User profiles for CA Fogarty
Carl A. FogartyPhD Candidate, Maynooth University. Verified email at mumail.ie Cited by 1253 |
Beyond shielding: the roles of glycans in the SARS-CoV-2 spike protein
…, AC Dommer, AM Harbison, CA Fogarty… - ACS central …, 2020 - ACS Publications
The ongoing COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 deaths …
2 (SARS-CoV-2) has resulted in more than 28,000,000 infections and 900,000 deaths …
[HTML][HTML] The case for post-predictional modifications in the AlphaFold Protein Structure Database
To the editor—AlphaFold2 has arrived to change workflows in structural biology, for good.
However, the algorithm does not account for essential modifications that affect protein …
However, the algorithm does not account for essential modifications that affect protein …
[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists in …
arisen naturally or through vaccination. Understanding the structure of the viral spike assists in …
[HTML][HTML] Fine-tuning the spike: role of the nature and topology of the glycan shield in the structure and dynamics of the SARS-CoV-2 S
The dense glycan shield is an essential feature of the SARS-CoV-2 spike (S) architecture,
key to immune evasion and to the activation of the prefusion conformation. Recent studies …
key to immune evasion and to the activation of the prefusion conformation. Recent studies …
[PDF][PDF] Citizen scientists create an exascale computer to combat COVID-19
The SARS-CoV-2/COVID-19 pandemic continues to threaten global health and socioeconomic
stability. Experiments have revealed snapshots of many of the viral components but …
stability. Experiments have revealed snapshots of many of the viral components but …
[HTML][HTML] SARS-CoV-2 simulations go exascale to capture spike opening and reveal cryptic pockets across the proteome
SARS-CoV-2 has intricate mechanisms for initiating infection, immune evasion/suppression,
and replication, which depend on the structure and dynamics of its constituent proteins. …
and replication, which depend on the structure and dynamics of its constituent proteins. …
[HTML][HTML] How and why plants and human N-glycans are different: Insight from molecular dynamics into the “glycoblocks” architecture of complex carbohydrates
CA Fogarty, AM Harbison… - Beilstein journal of …, 2020 - beilstein-journals.org
The N-glycosylation is one of the most abundant and diverse post-translational modifications
of proteins, implicated in protein folding and structural stability, and mediating interactions …
of proteins, implicated in protein folding and structural stability, and mediating interactions …
Obstetrics and gynecology—to be or not to be? Factors influencing one's decision
CA Fogarty, RG Bonebrake, AD Fleming… - American journal of …, 2003 - Elsevier
OBJECTIVE: The study was undertaken to determine factors influencing a medical student's
decision to choose obstetrics and gynecology (OB/GYN) versus another specialty. STUDY …
decision to choose obstetrics and gynecology (OB/GYN) versus another specialty. STUDY …
Restoring Protein Glycosylation with GlycoShape
During the past few years we have been witnessing a revolution in structural biology.
Leveraging on technological and computational advances, scientists can now resolve …
Leveraging on technological and computational advances, scientists can now resolve …
Oligomannose N-Glycans 3D Architecture and Its Response to the FcγRIIIa Structural Landscape
CA Fogarty, E Fadda - The Journal of Physical Chemistry B, 2021 - ACS Publications
Oligomannoses are evolutionarily the oldest class of N-glycans, where the arms of the
common pentasaccharide unit, ie, Manα(1–6)-[Manα(1–3)]-Manβ(1–4)-GlcNAcβ(1–4)-GlcNAcβ1-…
common pentasaccharide unit, ie, Manα(1–6)-[Manα(1–3)]-Manβ(1–4)-GlcNAcβ(1–4)-GlcNAcβ1-…