User profiles for CH Dean

Charlotte Dean

Verified email at imperial.ac.uk
Cited by 2182

Planar cell polarity in organ formation

DJ Henderson, DA Long, CH Dean - Current opinion in cell biology, 2018 - Elsevier
The planar cell polarity (PCP) pathway controls a variety of morphological events across
many species. During embryonic development, the PCP pathway regulates coordinated …

Interactions and survival of enteric viruses in soil materials

MD Sobsey, CH Dean, ME Knuckles… - Applied and …, 1980 - Am Soc Microbiol
There were marked differences in the abilities of eight different soil materials to remove and
retain viruses from settled sewage, but for each soil material the behavior of two different …

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis

…, A Greenfield, LA Niswander, CH Dean - Human molecular …, 2010 - academic.oup.com
The lungs are generated by branching morphogenesis as a result of reciprocal signalling
interactions between the epithelium and mesenchyme during development. Mutations that …

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

…, JO Connolly, AS Woolf, CH Dean - Human molecular …, 2010 - academic.oup.com
The planar cell polarity (PCP) pathway, incorporating non-canonical Wnt signalling, controls
embryonic convergent (CE) extension, polarized cell division and ciliary orientation. It also …

Microneedle-based intradermal delivery of the anthrax recombinant protective antigen vaccine

…, JP Dekker III, NG Harvey, CH Dean… - Infection and …, 2006 - Am Soc Microbiol
The recombinant protective antigen (rPA) of Bacillus anthracis is a promising anthrax vaccine.
We compared serum immunoglobulin G levels and toxin-neutralizing antibody titers in …

Endothelins control the timing of Schwann cell generation in vitro and in vivo

A Brennan, CH Dean, AL Zhang, DT Cass… - Developmental …, 2000 - Elsevier
Schwann cell precursors, derivatives of the neural crest, generate Schwann cells in a
process that is tightly timed, well characterized, and directly controlled by axonal signals, in …

[HTML][HTML] The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell …

…, Z Lalanne, S Wells, X Lu, DP Norris, CH Dean… - BMC developmental …, 2010 - Springer
Background The planar cell polarity (PCP) signalling pathway is fundamental to a number of
key developmental events, including initiation of neural tube closure. Disruption of the PCP …

[HTML][HTML] Pulmonary ORMDL3 is critical for induction of Alternaria-induced allergic airways disease

…, SA Walker, J Buckley, L Denney, CH Dean… - Journal of Allergy and …, 2017 - Elsevier
Background Genome-wide association studies have identified the ORM (yeast)-like protein
isoform 3 (ORMDL3) gene locus on human chromosome 17q to be a highly significant risk …

[HTML][HTML] Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour

…, J Sanderson, M Hind, M Griffiths, CH Dean - Nature …, 2019 - nature.com
Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic
and acute lung diseases. In addition, insufficient generation of alveoli results in …

[HTML][HTML] Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland

CH Dean, LAD Miller, AN Smith, D Dufort, RA Lang… - Developmental …, 2005 - Elsevier
Key gene families such as FGFs and BMPs are important mediators of branching morphogenesis.
To understand whether Wnt genes, and in particular, the canonical Wnt signaling …