The evolutionary survival of Mycobacterium tuberculosis, the cause of human tuberculosis,
depends on its ability to invade the host, replicate, and transmit infection. At its initial …

Tuberculosis, an ancient disease of mankind, remains one of the major infectious causes of
human death. We examine newly discovered facets of tuberculosis pathogenesis and …

Neutrophils are typically the first responders in host defense against invading pathogens,
which they destroy by both oxidative and nonoxidative mechanisms. However, despite a …

Mycobacterium tuberculosis (Mtb) enters the host in aerosol droplets deposited in lung alveoli,
where the bacteria first encounter lung-resident alveolar macrophages. We studied the …

Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in
producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination …

Immune control of persistent infection with Mycobacterium tuberculosis (Mtb) requires a
sustained pathogen-specific CD4 T cell response; however, the molecular pathways governing …

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum
identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests …

There is an urgent need for point-of-care tuberculosis (TB) diagnostic methods that are fast,
inexpensive, and operationally simple. Here, we report on a bright solvatochromic dye …

Several virulence lipids populate the outer cell wall of pathogenic mycobacteria. Phthiocerol
dimycocerosate (PDIM), one of the most abundant outer membrane lipids, plays important …

Mycobacterial infection leads to the formation of characteristic immune aggregates called
granulomas, a process accompanied by dramatic remodeling of the host vasculature. As …