The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of
the potential biological effects of metal wear debris. This review summarises data describing …

… The most extreme case was shown by the potassium depletion method where both ARPE-19
and Vero cells experienced an increased CME rates compared to non-inhibited cells, as …

Lately, concerns have arisen following the use of large metal-on-metal bearings in hip
replacements owing to reports of catastrophic soft-tissue reactions resulting in implant failure and …

In a post-mortem study, we compared subjects with metal implants with and without visible
wear with an age-matched control group to determine the extent and effects of dissemination …

Background: Metal-on-metal bearing surfaces have been reintroduced for use during total
hip replacement. To assess tissue reactions to various types of articulations, we studied the …

Wear debris from metal on polyethylene joint replacements causes asceptic loosening as a
result of an inflammatory reaction of macrophages to micron-sized particles. Metal on metal …

The increasing use of nanoparticles in medicine has raised concerns over their ability to gain
access to privileged sites in the body. Here, we show that cobalt–chromium nanoparticles (…

… Examination of all cases, except Case 4 (from which appropriate blocks were not available),
… The appearance of the cerebellum varied considerably from case to case. In Case 1 there …

We reviewed 22 486 consecutive autopsy reports in a single District General Hospital, from
1953 to 1992. Five hundred and eighty-one patients with fractures of the proximal femur (hip …

A prospective study was performed to investigate changes in metal levels and chromosome
aberrations in patients within 2 years of receiving metal-on-metal hip arthroplasties. There …