User profiles for Caesar Z Li
 | Caesar Z. LIJohnson & Johnson Innovative Medicine Verified email at g.ucla.edu Cited by 921 |
[HTML][HTML] DNA methylation predicts age and provides insight into exceptional longevity of bats
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (…
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation (…
[HTML][HTML] A mammalian methylation array for profiling methylation levels at conserved sequences
Infinium methylation arrays are not available for the vast majority of non-human mammals.
Moreover, even if species-specific arrays were available, probe differences between them …
Moreover, even if species-specific arrays were available, probe differences between them …
Universal DNA methylation age across mammalian tissues
Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks …
damage over time. Despite this, age can be accurately estimated by epigenetic clocks …
[HTML][HTML] DNA methylation clocks tick in naked mole rats but queens age more slowly than nonbreeders
Naked mole rats (NMRs) live an exceptionally long life, appear not to exhibit age-related
decline in physiological capacity and are resistant to age-related diseases. However, it has …
decline in physiological capacity and are resistant to age-related diseases. However, it has …
DNA methylation clocks for dogs and humans
DNA methylation profiles have been used to develop biomarkers of aging known as epigenetic
clocks, which predict chronological age with remarkable accuracy and show promise for …
clocks, which predict chronological age with remarkable accuracy and show promise for …
[HTML][HTML] Multi-species and multi-tissue methylation clocks for age estimation in toothed whales and dolphins
The development of a precise blood or skin tissue DNA Epigenetic Aging Clock for Odontocete
(OEAC) would solve current age estimation inaccuracies for wild odontocetes. Therefore, …
(OEAC) would solve current age estimation inaccuracies for wild odontocetes. Therefore, …
[HTML][HTML] Epigenetic models developed for plains zebras predict age in domestic horses and endangered equids
Effective conservation and management of threatened wildlife populations require an
accurate assessment of age structure to estimate demographic trends and population viability. …
accurate assessment of age structure to estimate demographic trends and population viability. …
[HTML][HTML] Epigenetic clock and methylation studies in cats
Human DNA methylation profiles have been used successfully to develop highly accurate
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …
biomarkers of aging (“epigenetic clocks”). Although these human epigenetic clocks are not …
Reversing age: dual species measurement of epigenetic age with a single clock
Young blood plasma is known to confer beneficial effects on various organs in mice. However,
it was not known whether young plasma rejuvenates cells and tissues at the epigenetic …
it was not known whether young plasma rejuvenates cells and tissues at the epigenetic …
[HTML][HTML] Reversal of biological age in multiple rat organs by young porcine plasma fraction
Young blood plasma is known to confer beneficial effects on various organs in mice and rats.
However, it was not known whether plasma from young adult pigs rejuvenates old rat …
However, it was not known whether plasma from young adult pigs rejuvenates old rat …