Translation elongation efficiency is largely thought of as the sum of decoding efficiencies for
individual codons. Here, we find that adjacent codon pairs modulate translation efficiency. …

The RNA recognition motif (RRM) is the most common RNA-binding domain in eukaryotes.
Differences in RRM sequences dictate, in part, both RNA and protein-binding specificities …

Background Arthrospira platensis (commonly known as spirulina) is a promising new platform
for low-cost manufacturing of biopharmaceuticals. However, full realization of the platform’…

Transcriptional enhancers are a primary mechanism by which tissue-specific gene
expression is achieved. Despite the importance of these regulatory elements in development, …

The use of the edible photosynthetic cyanobacterium Arthrospira platensis (spirulina) as a
biomanufacturing platform has been limited by a lack of genetic tools. Here we report genetic …

Arthrospira platensis (commonly known as spirulina) is a photosynthetic cyanobacterium 1 .
It is a highly nutritious food that has been consumed for decades in the US, and even longer …

Contemporary high-throughput technologies permit the rapid identification of transcription
factor (TF) target genes on a genome-wide scale, yet the functional significance of TFs …

Homeodomain (HD) proteins are a large family of evolutionarily conserved transcription factors
(TFs) having diverse developmental functions, often acting within the same cell types, yet …

Cancer stem cells likely survive chemotherapy or radiotherapy by acquiring mutations that
inactivate the endogenous apoptotic machinery or by cycling slowly. Thus, knowledge about …

We applied a mathematical framework originally used to model the effects of multiple inhibitors
on enzyme activity to guide the development a therapeutic antibody cocktail, LMN-201, to …