Vertebrate eggs are surrounded by an extracellular matrix with similar functions and conserved
individual components: the zona pellucida (ZP) glycoproteins. In mammals, chickens, …

Interactions between cytoplasmic proteins and membranes are critical for maintenance of
cell shape, cell adhesion and signal transduction. The known modes of interaction include …

The V(D)J recombination process insures the somatic diversification of immunoglobulin and
antigen T cell receptor encoding genes. This reaction is initiated by a DNA double-strand …

Ewes from the Booroola strain of Australian Mérino sheep are characterized by high ovulation
rate and litter size. This phenotype is due to the action of the FecB B allele of a major gene …

Secretion of cytolytic granules content at the immunological synapse is a highly regulated
process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of …

The regions surrounding the catalytic amino acids previously identified in a few "retaining" O-glycosyl
hydrolases (EC 3.2.1) have been analyzed by hydrophobic cluster analysis and …

Inherited mutations in BRCA1 predispose to breast and ovarian cancer, but the biological
function of the BRCA1 protein has remained largely elusive. The recent correspondence of …

MN is a transmembrane glycoprotein that has been detected in HeLa cells and in some
human carcinomas. The expression of MN protein in HeLa cells is regulated by cell density. In …

Innate immunity to viral infection involves induction of the type I IFN response; however,
dysfunctional regulation of this pathway leads to inappropriate inflammation. Here, we evaluated …

HP1-type chromodomain proteins self-associate as well as interact with the inner nuclear
membrane protein LBR (lamin Breceptor) and transcriptional coactivators TIF1α and TIF1β. …