User profiles for Cameron P Bracken
Cameron BrackenAssociate Professor, Centre for Cancer Biology, University of South Australia Verified email at unisa.edu.au Cited by 8193 |
A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
CP Bracken, PA Gregory, N Kolesnikoff, AG Bert… - Cancer research, 2008 - AACR
Epithelial to mesenchymal transition occurs during embryologic development to allow tissue
remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. …
remodeling and is proposed to be a key step in the metastasis of epithelial-derived tumors. …
[HTML][HTML] The human mitochondrial transcriptome
…, MA Smith, AMJ Shearwood, E Haugen, CP Bracken… - Cell, 2011 - cell.com
The human mitochondrial genome comprises a distinct genetic system transcribed as precursor
polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, …
polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, …
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is a form of cellular plasticity that is critical for
embryonic development and tumor metastasis. A double-negative feedback loop involving the …
embryonic development and tumor metastasis. A double-negative feedback loop involving the …
Experimental strategies for microRNA target identification
MicroRNAs (miRNAs) are important regulators of eukaryotic gene expression in most biological
processes. They act by guiding the RNAi-induced silencing complex (RISC) to partially …
processes. They act by guiding the RNAi-induced silencing complex (RISC) to partially …
A network-biology perspective of microRNA function and dysfunction in cancer
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non-…
and consequently have roles in many pathologies, including cancer. These small non-…
MicroRNAs as regulators of epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) describes the molecular reprogramming and
phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile …
phenotypic changes involved in the conversion of polarised immotile epithelial cells to motile …
IsomiRs–the overlooked repertoire in the dynamic microRNAome
CT Neilsen, GJ Goodall, CP Bracken - Trends in genetics, 2012 - cell.com
The development of deep sequencing has enabled the identification of novel microRNAs (miRNAs),
leading to a growing appreciation for the fact that individual miRNAs can be …
leading to a growing appreciation for the fact that individual miRNAs can be …
[HTML][HTML] Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment
CP Bracken, AO Fedele, S Linke, W Balrak… - Journal of Biological …, 2006 - ASBMB
The hypoxia-inducible factor (HIF)-1α and HIF-2α are closely related, key transcriptional
regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of …
regulators of the hypoxic response, countering a low oxygen situation with the up-regulation of …
Mutant p53 drives invasion in breast tumors through up-regulation of miR-155
Loss of p53 function is a critical event during tumorigenesis, with half of all cancers harboring
mutations within the TP53 gene. Such events frequently result in the expression of a …
mutations within the TP53 gene. Such events frequently result in the expression of a …
[HTML][HTML] On measuring miRNAs after transient transfection of mimics or antisense inhibitors
The ability to alter microRNA (miRNA) abundance is crucial for studying miRNA function. To
achieve this there is widespread use of both exogenous double-stranded miRNA mimics for …
achieve this there is widespread use of both exogenous double-stranded miRNA mimics for …