Xenopus leads the way: Frogs as a pioneering model to understand the human brain

CRT Exner, HR Willsey - genesis, 2021 - Wiley Online Library
From its long history in the field of embryology to its recent advances in genetics, Xenopus
has been an indispensable model for understanding the human brain. Foundational studies …

[PDF][PDF] Parallel in vivo analysis of large-effect autism genes implicates cortical neurogenesis and estrogen in risk and resilience

HR Willsey, CRT Exner, Y Xu, A Everitt, N Sun, B Wang… - Neuron, 2021 - cell.com
Gene Ontology analyses of autism spectrum disorders (ASD) risk genes have repeatedly
highlighted synaptic function and transcriptional regulation as key points of convergence. …

[HTML][HTML] Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions

TL Gallagher, JA Arribere, PA Geurts, CRT Exner… - Developmental …, 2011 - Elsevier
Rbfox RNA binding proteins are implicated as regulators of phylogenetically-conserved
alternative splicing events important for muscle function. To investigate the function of rbfox …

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos

HR Willsey, Y Xu, A Everitt, J Dea, CRT Exner… - …, 2020 - journals.biologists.com
DYRK1A [dual specificity tyrosine-(Y)-phosphorylation-regulated kinase 1 A] is a high-confidence
autism risk gene that encodes a conserved kinase. In addition to autism, individuals …

[HTML][HTML] Katanin-like protein Katnal2 is required for ciliogenesis and brain development in Xenopus embryos

HR Willsey, P Walentek, CRT Exner, Y Xu, AB Lane… - Developmental …, 2018 - Elsevier
Microtubule remodeling is critical for cellular and developmental processes underlying
morphogenetic changes and for the formation of many subcellular structures. Katanins are …

Correction: The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos

HR Willsey, Y Xu, A Everitt, J Dea, CRT Exner… - …, 2020 - journals.biologists.com
Cameron RT Exner, Cameron RT ExnerCameron RT Exner

[HTML][HTML] sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis

CRT Exner, AY Kim, SM Mardjuki, RM Harland - Developmental Biology, 2017 - Elsevier
The embryonic precursor of the vertebrate central nervous system, the neural plate, is
patterned along the anterior-posterior axis and shaped by morphogenetic movements early in …

The atypical RNA-binding protein Taf15 regulates dorsoanterior neural development through diverse mechanisms in Xenopus tropicalis

CS DeJong, DS Dichmann, CRT Exner, Y Xu… - …, 2021 - journals.biologists.com
The FET family of atypical RNA-binding proteins includes Fused in sarcoma (FUS), Ewing's
sarcoma (EWS) and the TATA-binding protein-associate factor 15 (TAF15). FET proteins are …

Complications associated with defibrillation threshold testing: the Canadian experience

…, F Philippon, P Guerra, S Kimber, D Cameron… - Heart rhythm, 2008 - Elsevier
Exner and Dr. F Philippon have received research grants/… Exner has received research
grants/support from GE Healthcare, … Exner has received honoraria from GE Healthcare, and Dr. C. …

Radiographic predictors of lead conductor fracture

…, E Crystal, F Ayala-Paredes, D Cameron… - Circulation …, 2014 - Am Heart Assoc
Background— Lead fracture is a limiting factor in high voltage lead durability. Fractures
noted with the Medtronic Fidelis leads provide an opportunity to examine factors captured on …