Understanding how modifications to the ribosome affect function has implications for studying
ribosome biogenesis, building minimal cells, and repurposing ribosomes for synthetic …

Molecular translation systems provide a genetically encoded framework for protein synthesis,
which is essential for all life. Engineering these systems to incorporate non-canonical …

RNA-based macromolecular machines, such as the ribosome, have functional parts reliant
on structural interactions spanning sequence-distant regions. These features limit …

The ribosome is a macromolecular machine that catalyzes the sequence-defined polymerization
of L-α-amino acids into polypeptides. The catalysis of peptide bond formation between …

Functional design of ribosomes with mutant ribosomal RNA (rRNA) can expand
opportunities for understanding molecular translation, building cells from the bottom-up, and …

Understanding how modifications to the ribosome affect function has implications for studying
ribosome biogenesis, building minimal cells, and repurposing ribosomes for synthetic …

The biosynthetic capability of the bacterial ribosome motivates efforts to understand and
harness sequence-optimized versions for synthetic biology. However, functional differences …

A genomically recoded Escherichia coli strain that lacks all amber codons and release factor
1 (C321.∆A) enables efficient genetic encoding of chemically diverse non‐canonical amino …

RNA-based macromolecular machines, such as the ribosome, have functional parts reliant
on structural interactions spanning sequence-distant regions. These features limit …

A genomically recoded Escherichia coli strain that lacks all amber codons and release factor
1 (C321.ΔA) enables efficient genetic encoding of chemically diverse, non-canonical amino …