… Author links open overlay panel Camilla Luni 1 2 , Elena Serena 1 2 , Nicola Elvassore 1
2 … Luni, HC Feldman, M. Pozzobon, P. De Coppi, CD Meinhart, N. …

We report that the efficiency of reprogramming human somatic cells to induced pluripotent
stem cells (hiPSCs) can be dramatically improved in a microfluidic environment. Microliter-…

Microengineering human “organs-on-chips” remains an open challenge. Here, we describe
a robust microfluidics-based approach for the differentiation of human pluripotent stem cells …

Organoids have extensive therapeutic potential and are increasingly opening up new avenues
within regenerative medicine. However, their clinical application is greatly limited by the …

The reproduction of reliable in vitro models of human skeletal muscle is made harder by the
intrinsic 3D structural complexity of this tissue. Here we coupled engineered hydrogel with …

An integrative approach based on microfluidic design and stem cell biology enables capture
of the spatial-temporal environmental evolution underpinning epigenetic remodeling and …

Micropatterning techniques and substrate engineering are becoming useful tools to
investigate several aspects of cell–cell interaction biology. In this work, we rationally study how …

COVID-19 typically manifests as a respiratory illness, but several clinical reports have described
gastrointestinal symptoms. This is particularly true in children in whom gastrointestinal …

Since the discovery of human somatic cell reprogramming, human induced pluripotent stem
cells (hiPSC) have been increasingly recognized as the landmark for development of organs…

Pancreatic β-cell dysfunction is a diagnostic criterion of Type 2 diabetes and includes defects
in glucose transport and insulin secretion. In healthy individuals, β-cells maintain plasma …