The spike aspartic acid–614 to glycine (D614G) substitution is prevalent in global severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains, but its effects on viral …

Mucus clearance is the primary defense mechanism that protects airways from inhaled
infectious and toxic agents. In the current gel-on-liquid mucus clearance model, a mucus gel is …

The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely
involves poor mucus clearance. A recent model of mucus clearance predicts that mucus flow …

Muco-obstructive lung diseases are typically associated with high risks of COVID-19 severity;
however, allergic asthma showed reduced susceptibility. To investigate viral spread, …

Rationale: MUC5AC and MUC5B are the predominant gel-forming mucins in the mucus layer
of human airways. Each mucin has distinct functions and site-specific expression. However…

Mucus, with its burden of inspired particulates and pathogens, is cleared from mucosal
surfaces of the airways by cilia beating within the periciliary layer (PCL). The PCL is held to be “…

MUC5AC, a major gel-forming mucin expressed in the lungs, is secreted at increased rates
in response to infectious agents, implying that mucins exert a protective role against inhaled …

Although destructive airway disease is evident in young children with cystic fibrosis (CF),
little is known about the nature of the early CF lung environment triggering the disease. To …

Single-dose administration of beta-adrenoceptor agonists produces bronchodilation and
inhibits airway hyperresponsiveness (AHR), and is the standard treatment for the acute relief of …

Our current understanding of cystic fibrosis (CF) has revealed that the biophysical properties
of mucus play a considerable role in the pathogenesis of the disease in view of the fact that …