Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of
tractable cellular and animal models. Steatosis also occurs in cats, where it can cause …

The Plasmodium vivax Duffy-binding protein (DBP) is a prime target of the protective immune
response and a promising vaccine candidate for P. vivax malaria. Naturally acquired …

The absence of the Duffy protein at the surface of erythrocytes was considered for decades
to confer full protection against Plasmodium vivax as this blood group is the receptor for the …

The interaction between Plasmodium vivax Duffy binding protein (PvDBP) and Duffy antigen
receptor for chemokines (DARC) has been described as critical for the invasion of human …

Antigenic variation, the capacity to produce a range of variable antigens, is a well-described
strategy of Plasmodium and other parasites to evade host immunity. Here, we show that …

Drug resistance and a dire lack of transmission-blocking antimalarials hamper malaria
elimination. Here, we present the pantothenamide MMV693183 as a first-in-class acetyl-CoA …

Plasmodium vivax infects hepatocytes to form schizonts that cause blood infection, or
dormant hypnozoites that can persist for months in the liver before leading to relapsing blood …

Our understanding of the structure and regulation of Plasmodium vivax genes is limited by
our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must …

Tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are pro-inflammatory cytokines
involved in acute and chronic inflammatory diseases. Indeed, immunotherapy blocking these …

Plasmodium vivax invasion of reticulocytes relies on distinct receptor-ligand interactions
between the parasite and host erythrocytes. Engagement of the highly polymorphic domain II of …