Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma
Background and aims Chronic inflammation induced by chronic hepatitis B virus (HBV) infection
increases the risk of hepatocellular carcinoma (HCC). However, little is known about the …
increases the risk of hepatocellular carcinoma (HCC). However, little is known about the …
[HTML][HTML] Hypoxia‐driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC
Background and Aims Hypoxia is one of the central players in shaping the immune context
of the tumor microenvironment (TME). However, the complex interplay between immune cell …
of the tumor microenvironment (TME). However, the complex interplay between immune cell …
Delineation of an immunosuppressive gradient in hepatocellular carcinoma using high-dimensional proteomic and transcriptomic analyses
The recent development of immunotherapy as a cancer treatment has proved effective over
recent years, but the precise dynamics between the tumor microenvironment (TME), …
recent years, but the precise dynamics between the tumor microenvironment (TME), …
Immune activation underlies a sustained clinical response to Yttrium-90 radioembolisation in hepatocellular carcinoma
Objectives Yttrium-90 (Y90)-radioembolisation (RE) significantly regresses locally advanced
hepatocellular carcinoma and delays disease progression. The current study is designed to …
hepatocellular carcinoma and delays disease progression. The current study is designed to …
[HTML][HTML] Single-cell transcriptomics and surface epitope detection in human brain epileptic lesions identifies pro-inflammatory signaling
P Kumar, A Lim, SN Hazirah, CJH Chua, A Ngoh… - Nature …, 2022 - nature.com
Epileptogenic triggers are multifactorial and not well understood. Here we aimed to address
the hypothesis that inappropriate pro-inflammatory mechanisms contribute to the …
the hypothesis that inappropriate pro-inflammatory mechanisms contribute to the …
[HTML][HTML] Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in hepatocellular carcinoma
…, S Suthen, S A'Azman, G Gien, CJ Lim, C Chua… - Journal of …, 2022 - Elsevier
Background & Aims While immune checkpoint blockade (ICB) has shown promise in patients
with hepatocellular carcinoma (HCC), it is associated with modest response rates and …
with hepatocellular carcinoma (HCC), it is associated with modest response rates and …
Ex vivo–expanded but not in vitro–induced human regulatory T cells are candidates for cell therapy in autoimmune diseases thanks to stable demethylation of the …
M Rossetti, R Spreafico, S Saidin, C Chua… - The Journal of …, 2015 - journals.aai.org
Regulatory T cell (Treg) therapy is a promising approach for transplant rejection and severe
autoimmunity. Unfortunately, clinically meaningful Treg numbers can be obtained only upon …
autoimmunity. Unfortunately, clinically meaningful Treg numbers can be obtained only upon …
[HTML][HTML] Neutralizing activity and SARS-CoV-2 vaccine mRNA persistence in serum and breastmilk after BNT162b2 vaccination in lactating women
Background There is limited information on the functional neutralizing capabilities of breastmilk
SARS-CoV-2-specific antibodies and the potential adulteration of breastmilk with vaccine …
SARS-CoV-2-specific antibodies and the potential adulteration of breastmilk with vaccine …
TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis
…, A Consolaro, JY Leong, C Chua… - Annals of the …, 2017 - ard.bmj.com
Objectives The imbalance between effector and regulatory T (Treg) cells is crucial in the
pathogenesis of autoimmune arthritis. Immune responses are often investigated in the blood …
pathogenesis of autoimmune arthritis. Immune responses are often investigated in the blood …
[HTML][HTML] Immunological hallmarks for clinical response to BCG in bladder cancer
Intravesical Bacillus Calmette-Guerin (BCG) is an effective immunotherapy for non-muscle
invasive bladder cancer (NMIBC). However, recurrence and progression remain frequent …
invasive bladder cancer (NMIBC). However, recurrence and progression remain frequent …