… But when cells have a decreased expression of MHC-I, which can occur during certain viral
infections or in tumors, they can become target for NK cell killing. The process by which NK …

… To our knowledge, this is the first report to show how autologous cancer exome data can be
used to reveal T-cell responses against patient-specific neoantigens in humans. The ATR S>L …

Evolutionary modelling studies indicate less than a century has passed since the most recent
common ancestor of the HIV-1 pandemic strains and, in that time frame, an extraordinarily …

T-cells have to recognize peptides presented on MHC molecules to be activated and elicit
their effector functions. Several studies demonstrate that some peptides are more …

… First, we will demonstrate how the predictive performance can be … In this way, we can
directly point out the source of … (2) Can one find signs of adaptation between the specificity …

We present a predictive method that can simulate an essential step in the antigen
presentation in higher vertebrates, namely the step involving the proteasomal degradation of …

… can be classified into two types: humoral immunity, mediated by antibodies, which are secreted
by B lymphocytes and can … functions independently and can be recombinantly produced …

… can recognize antigens in their native form, we also show how structural information of a
protein can … Chapter 14 explains how all the methods described in this book can be integrated …

BACKGROUND: HLA class-I mismatches selectively induce antibody formation after kidney
transplantation. The de novo development of donor-specific IgG HLA class-I antibodies may …

Vaccination clearly decreases coronavirus disease 2019 (COVID-19) mortality; however,
they also impose selection pressure on the virus, which promotes the evolution of immune …