… Cara C. Hardy conceptualized and wrote this manuscript. Ron Korstanje aided in manuscript
preparation and gave invaluable input for the direction and presentation of the topics …

Aims The prevalence of urinary dysfunction increases with age, yet therapies are often
suboptimal. Incomplete understanding of the linkages between system, organ, and tissue …

Volume hyposensitivity resulting from impaired sympathetic detrusor relaxation during bladder
filling contributes to detrusor underactivity (DU) associated with aging. Detrusor tension …

A geroscience-informed approach to the increasing prevalence of bladder control problems
in older adults requires understanding the impact of aging on dynamic mechanisms that …

The urinary bladder functions as a reservoir to store and extrude liquid bodily waste. Significant
debate exists as to this tissue’s cellular composition and genes associated with their …

Aims While most Alzheimer's disease (AD) research emphasizes cognitive and behavioral
abnormalities, lower urinary tract symptoms (LUTS) are observed in a third of AD patients, …

Bothersome urinary symptoms plague many older adults and disproportionally affect women.
Under reporting of symptoms and general stigma / embarrassment associated with …

The Hyperpolarization activated, cyclic nucleotide gated (HCN) channel is a candidate
mediator of neuroendocrine influence over detrusor tonus during filling. In other tissues, HCN …

Multiple sclerosis (MS) is a chronic, progressively debilitating demyelinating disease of the
central nervous system (CNS). Nearly 80% of MS patients experience lower urinary tract …

Medical professionals seem to interpret their uses of humor very differently from those outside
the medical profession. Nurses and physicians argue that humor is necessary for them to …