Endogenous homeostatic mechanisms can restore normal neuronal function following
cocaine-induced neuroadaptations. Such mechanisms may be exploited to develop novel …

Neuronal alternative splicing is a key gene regulatory mechanism in the brain. However, the
spliceosome machinery is insufficient to fully specify splicing complexity. In considering the …

Background Sex differences in the expression and prevalence of trauma- and stress-related
disorders have led to a growing interest in the sex-specific molecular and epigenetic …

Studies of the mammalian nervous system have revealed widespread epigenetic regulation
underlying gene expression intrinsic to basic neurobiological function as well as …

Delivery of molecular tools for targeted epigenome editing in rodent brain can be facilitated
by the use of viral vector-mediated gene transfer coupled with stereotaxic surgery techniques…

Delivery of engineered zinc-finger proteins (ZFPs) for targeted epigenetic remodeling in
rodent brain can be facilitated by the use of viral vector-mediated gene transfer coupled with …

Alternative splicing is a key mechanism for neuronal gene regulation, and is grossly altered
in mouse brain reward regions following investigator-administered cocaine. It is well …

NAFLD is the most common chronic liver disease worldwide, occurring in both obese and
lean patients. It can lead to life-threatening liver diseases and nonhepatic complications, such …

… Carissa carandas fruit was found to have an antioxidant IC 50 value of 62.97 μg/ml as
evaluated using1,1 diphenyl-2-picrylhydrazyl (DPPH) radical scavenging but with little potential …

… anthocyanin content and vitamin C content of Carissa carandas were evaluated in this
study. The resulting antioxidant activity could be related to the total phenolic content. The …