Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the neural …

Many photoreceptor degenerations initially affect rods, secondarily leading to cone death. It
has long been assumed that the surviving neural retina is largely resistant to this sensory …

Purpose A connectome is a comprehensive description of synaptic connectivity for a neural
domain. Our goal was to produce a connectome data set for the inner plexiform layer of the …

Retinal guanylate cyclases 1 and 2 (GC1 and GC2) are responsible for synthesis of cyclic
GMP in rods and cones, but their individual contributions to phototransduction are unknown. …

Circuitry mapping of metazoan neural systems is difficult because canonical neural regions (regions
containing one or more copies of all components) are large, regional borders are …

Age-related macular degeneration (AMD) is a progressive retinal degeneration resulting in
central visual field loss, ultimately causing debilitating blindness. AMD affects 18% of …

Connectomics is a strategy for mapping complex neural networks based on high-speed
automated electron optical imaging, computational assembly of neural data volumes, web-…

Retinal degenerative diseases that progress through loss of photoreceptors initiate a sequence
of events that culminates in negative remodelling of the retina. Initially, photoreceptor …

Stargardt type 3 (STGD3) disease is a juvenile macular dystrophy caused by mutations in the
ELOVL4 (Elongation of very long chain fatty acids 4) gene. Its protein product, ELOVL4, is …

Heterotrimeric kinesin-II is a molecular motor localized to the inner segment, connecting
cilium and axoneme of mammalian photoreceptors. Our purpose was to identify the role of …